Do non-steroidal anti-inflammatory drugs have an effect on gastric cell turnover?
Aliment Pharmacol Ther
; 9(5): 575-9, 1995 Oct.
Article
en En
| MEDLINE
| ID: mdl-8580281
ABSTRACT
AIM:
To study the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on gastric cell turnover using an in vitro immunohistochemical method of bromodeoxyuridine (BrDU) uptake.METHODS:
Thirty patients undergoing routine upper gastrointestinal endoscopy were studied. Sixteen had taken NSAIDs daily for more than 3 months and there were 14 age-matched controls. Endoscopic gastric antral biopsies were obtained and stained immediately using the BrDU technique. Cell proliferation was expressed as a labelling index percentage (LI%) defined as the number of BrDU-labelled nuclei in 10 gastric glands, expressed as a percentage of the total cells in the gastric gland.RESULTS:
Gastric infection with Helicobacter pylori was excluded in all patients. Of the 16 patients on NSAIDs, four had gastritis, four had erosions or ulceration and eight had a normal examination. Endoscopy was normal in all patients in the control group. The LI% (mean +/- S.E.M.) in the entire NSAID group was 4.09 +/- 0.29 and in the control group 3.57 +/- 0.29. No significant difference was observed. In the NSAID patients with gastritis and erosions or ulceration, the LI% was 4.99 +/- 0.61 and 3.07 +/- 0.32, respectively. There was no significant difference in LI% between the endoscopic subgroups of patients on NSAIDs or between patients on NSAIDs who had normal endoscopy and the control patients.CONCLUSION:
These results provide evidence that refutes the hypothesis that the prevalence of NSAID gastropathy is due to an effect on gastric cell turnover.
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Banco de datos:
MEDLINE
Asunto principal:
Antro Pilórico
/
Antiinflamatorios no Esteroideos
/
Mucosa Gástrica
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
1995
Tipo del documento:
Article