Xenotransplantation: recent progress and current perspectives.
Curr Opin Immunol
; 8(5): 721-8, 1996 Oct.
Article
en En
| MEDLINE
| ID: mdl-8902399
ABSTRACT
A severe shortage of human transplant donors has sparked interest in the use of animals as a source of organs and tissues for transplantation. Clinical application of xenotransplantation is limited in large part by the severe immunological reaction of the recipient against the graft. This immunological reaction is mediated initially by components of natural immunity such as xenoreactive antibodies, complement and natural killer cells and later by elicited humoral and cellular immune responses which act in concert to disrupt the function of the endothelial lining of blood vessels. The past few years have brought considerable progress in elucidating the molecular and cellular basis of xenograft rejection and in developing strategies to overcome xenograft rejection.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Trasplante Heterólogo
/
Inmunología del Trasplante
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
1996
Tipo del documento:
Article