Female pseudohermaphroditism due to congenital adrenal hyperplasia complicated by adenocarcinoma of the prostate and clear cell carcinoma of the endometrium.
Am J Clin Pathol
; 106(5): 660-4, 1996 Nov.
Article
en En
| MEDLINE
| ID: mdl-8929478
ABSTRACT
The presence of prostatic glandular tissue in female pseudohermaphrodites has previously been documented. However, prostatic neoplasia in this clinical setting has not been reported. A karyotypic female with congenital adrenal hyperplasia due to 21-hydroxylase deficiency developed a prostatic adenocarcinoma associated with elevated serum prostatic specific antigen levels and osteoblastic skeletal metastases. This demonstrates that this tissue in pseudohermaphrodites can become malignant. In addition, the patient subsequently developed clear cell carcinoma of the endometrium, possibly related to radiation therapy for the prostatic adenocarcinoma. This demonstrates that female pseudohermaphrodites may be at risk not only for malignancies seen in genotypic females but also prostate cancer.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Trastornos del Desarrollo Sexual
/
Adenocarcinoma
/
Neoplasias Endometriales
/
Hiperplasia Suprarrenal Congénita
/
Adenocarcinoma de Células Claras
Tipo de estudio:
Etiology_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1996
Tipo del documento:
Article