Amoxycillin/clavulanic acid prophylaxis in elective colorectal surgery: a prospective randomized trial.
J Hosp Infect
; 37(1): 55-64, 1997 Sep.
Article
en En
| MEDLINE
| ID: mdl-9321729
ABSTRACT
In a randomized trial of 440 patients undergoing elective colorectal surgery, the prophylactic efficacy and the safety of amoxycillin/clavulanic acid were compared with that of a control regimen of clindamycin and gentamicin. Surgical wound healing was assessed by the ASEPSIS points scale; it was normal in 86% of patients and the scores for both groups were not statistically different (amoxycillin/clavulanic acid 11.1; clindamycin + gentamicin 10.9). Intra-abdominal infections were more frequent in the clindamycin + gentamicin arm of the study (Fisher's exact test, P = 0.035). It is concluded that amoxycillin/clavulanic acid is as effective and safe as clindamycin + gentamicin in the prevention of wound infection and may provide better protection against intra-abdominal infections.
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Banco de datos:
MEDLINE
Asunto principal:
Enfermedades del Recto
/
Enfermedades del Colon
/
Profilaxis Antibiótica
/
Combinación Amoxicilina-Clavulanato de Potasio
/
Quimioterapia Combinada
/
Antibacterianos
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1997
Tipo del documento:
Article