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Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine adjuvant immunotherapy for splenic hemangiosarcoma in the dog: a randomized multi-institutional clinical trial.
Vail, D M; MacEwen, E G; Kurzman, I D; Dubielzig, R R; Helfand, S C; Kisseberth, W C; London, C A; Obradovich, J E; Madewell, B R; Rodriguez, C O.
Afiliación
  • Vail DM; Departments of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Clin Cancer Res ; 1(10): 1165-70, 1995 Oct.
Article en En | MEDLINE | ID: mdl-9815908
ABSTRACT
Canine splenic hemangiosarcoma (HSA) is a spontaneous tumor with high metastatic potential. Despite surgical excision, most dogs die within 2 months of diagnosis as a result of widespread visceral metastasis. This study was designed to determine the efficacy of liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE) when used in combination with splenectomy and systemic chemotherapy for the treatment of HSA in the dog. Thirty-two dogs with HSA and without gross evidence of metastases were treated with splenectomy, stratified by clinical stage, and randomized to receive doxorubicin/cyclophosphamide chemotherapy and either L-MTP-PE immunotherapy or lipid equivalent (placebo liposomes). Dogs were subsequently followed to determine disease-free survival and overall survival times. The effects of L-MTP-PE on serum tumor necrosis factor-alpha and interleukin 6 activity were assessed on a small subset of dogs. Dogs receiving L-MTP-PE had significantly prolonged disease-free survival (P = 0.037) and overall survival (P = 0.029) compared with dogs receiving placebo. Dogs with clinical stage I disease had significantly prolonged disease-free survival (P = 0. 026) and overall survival (P = 0.017) compared with dogs with clinical stage II disease. Dogs receiving L-MTP-PE had significantly greater serum tumor necrosis factor-alpha (P < 0.001) and interleukin 6 (P = 0.007) activities compared with placebo-treated dogs. L-MTP-PE has significant antimetastatic activity in highly malignant, spontaneously occurring, splenic HSA in the dog. Canine HSA may have potential as a large animal model for additional investigation of antimetastatic chemoimmunotherapy.
Asunto(s)
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Banco de datos: MEDLINE Asunto principal: Fosfatidiletanolaminas / Neoplasias del Bazo / Acetilmuramil-Alanil-Isoglutamina / Adyuvantes Inmunológicos / Enfermedades de los Perros / Hemangiosarcoma / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 1995 Tipo del documento: Article
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Banco de datos: MEDLINE Asunto principal: Fosfatidiletanolaminas / Neoplasias del Bazo / Acetilmuramil-Alanil-Isoglutamina / Adyuvantes Inmunológicos / Enfermedades de los Perros / Hemangiosarcoma / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 1995 Tipo del documento: Article