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Therapeutic Methods and Therapies TCIM
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1.
Cochlear Implants Int ; 20(1): 12-22, 2019 01.
Article in English | MEDLINE | ID: mdl-30293522

ABSTRACT

OBJECTIVE: This study examined the patterns of recognition of Arabic consonants, via information transmission analysis for phonological features, in a group of Malay children with normal hearing (NH) and cochlear implants (CI). METHOD: A total of 336 and 616 acoustic tokens were collected from six CI and 11 NH Malay children, respectively. The groups were matched for hearing age and duration of exposure to Arabic sounds. All the 28 Arabic consonants in the form of consonant-vowel /a/ were presented randomly twice via a loudspeaker at approximately 65 dB SPL. The participants were asked to repeat verbally the stimulus heard in each presentation. RESULTS: Within the native Malay perceptual space, the two groups responded differently to the Arabic consonants. The dispersed uncategorized assimilation in the CI group was distinct in the confusion matrix (CM), as compared to the NH children. Consonants /h/, /tˁ/, /sˁ/ and /ʁ/ were difficult for the CI children, while the most accurate item was /k/ (84%). The CI group transmitted significantly reduced information, especially for place feature transmission, then the NH group (p < 0.001). Significant interactions between place-hearing status and manner-hearing status were also obtained, suggesting there were information transmission differences in the pattern of consonants recognition between the study groups. CONCLUSION: CI and NH Malay children may be using different acoustic cues to recognize Arabic sounds, which contribute to the different assimilation categories' patterns within the Malay perceptual space.


Subject(s)
Acoustic Stimulation/psychology , Cochlear Implantation , Cochlear Implants/psychology , Deafness/psychology , Speech Perception , Case-Control Studies , Child , Cues , Deafness/surgery , Female , Humans , Language , Malaysia , Male , Phonetics
2.
Chem Pharm Bull (Tokyo) ; 58(8): 1085-7, 2010 Aug.
Article in English | MEDLINE | ID: mdl-20686264

ABSTRACT

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 2D NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.


Subject(s)
Apocynaceae/chemistry , Carbolines/pharmacology , Plant Extracts/pharmacology , Plant Stems/chemistry , Vasodilator Agents/pharmacology , Animals , Aorta/drug effects , Aorta/metabolism , Carbolines/chemistry , Carbolines/isolation & purification , Male , Molecular Structure , Nitric Oxide/metabolism , Plant Extracts/chemistry , Plant Extracts/isolation & purification , Plants, Medicinal/chemistry , Rats , Rats, Wistar , Stereoisomerism , Vasodilator Agents/chemistry , Vasodilator Agents/isolation & purification
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