ABSTRACT
Experiments showed that drinking water supplemented with a complex of 12 microelements and organic acids stimulates body mass gain and strengthening of radioresistance in mice. Obviously, availability of water with the mineral and organic complex before and after irradiation was the factor in survival of a part of mice exposed to the absolutely lethal dose (7.6 Gy from gamma-quanta 60Co) and reduction of chromosomal aberrations rate in bone marrow cells in consequence of nonlethal (1 Gy) irradiation.
Subject(s)
Bone Marrow Cells/pathology , Chromosome Aberrations/radiation effects , Gamma Rays/adverse effects , Minerals/pharmacology , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents/pharmacology , Animals , Bone Marrow Cells/radiation effects , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Radiation Injuries, Experimental/metabolism , Radiation Injuries, Experimental/pathologyABSTRACT
The experiments with M. fasciculata monkeys exposed to 137Cs gamma-radiation with a dose of 6.9 Gy showed that Latranum, a blocker of serotonin 5-HT3 receptors, is a more efficient antiemetic than Dimetphramidum, a D2 dophamin lytic. This is suggested by fewer animals with emetic reaction of by less severe vomiting in case they have any. The results agree well with a hypothesis that serotonin receptors are dominant in the chemoreceptor trigger zone of monkeys.
Subject(s)
Antiemetics/pharmacology , Benzamides/pharmacology , Dopamine Antagonists/pharmacology , Dopamine D2 Receptor Antagonists , Radiation Injuries, Experimental/complications , Receptors, Serotonin/drug effects , Serotonin Antagonists/pharmacology , Vomiting/etiology , Animals , Antiemetics/therapeutic use , Benzamides/therapeutic use , Disease Models, Animal , Dopamine Antagonists/therapeutic use , Drug Evaluation, Preclinical , Female , Gamma Rays , Macaca fascicularis , Male , Radiation Injuries, Experimental/drug therapy , Receptors, Dopamine D2/drug effects , Receptors, Dopamine D2/radiation effects , Receptors, Serotonin/radiation effects , Receptors, Serotonin, 5-HT3 , Serotonin Antagonists/therapeutic use , Time Factors , Vomiting/drug therapy , Whole-Body IrradiationABSTRACT
Simulation of cytopenia by injection of cyclophosphamide (100 mg/kg) or by exposure to ionizing radiation (4 Gy) was shown to cause in mice similar, by the severity and rate of development, transient inhibition of haemopoiesis which was somewhat more persistent after irradiation. Glucosaminylmuramyl dipeptide applied after the above effects promoted the haemopoiesis recovery.