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1.
Agri ; 35(2): 117-118, 2023 Apr.
Article in English | MEDLINE | ID: mdl-37052162

ABSTRACT

In this article, a cosmetic complication case secondary to bilateral supraorbital and supratrochlear nerve block with low dose local anesthetic and dexamethasone combination is presented.


Subject(s)
Anesthesia, Conduction , Nerve Block , Humans , Anesthetics, Local/adverse effects , Anesthesia, Local , Nerve Block/adverse effects
2.
World Neurosurg ; 175: e296-e302, 2023 Jul.
Article in English | MEDLINE | ID: mdl-36965663

ABSTRACT

OBJECTIVE: To demonstrate the effect of medical ozone therapy on the development of epidural fibrosis. METHODS: A total of 25 Sprague-Dawley male rats were randomly divided into 3 groups: a control group (L3-L4 laminectomy only), a systemic ozone therapy (SOT) group (L3-L4 laminectomy only + intraperitoneal 15 mL [30 µg/mL] ozone), and a local ozone therapy (LOT) group (L3-L4 laminectomy only + subcutaneous 15 mL [30 µg/mL] ozone). Ozone therapy was administered 4 times on a 3-day interval during the wound-healing process, with the first dose immediately administered after surgery. The effects of ozone therapy on vascular endothelial growth factor, inflammation, and epidural fibrosis between groups were evaluated. RESULTS: Staining with vascular endothelial growth factor was significantly less in the group that received SOT compared with the control group (P = 0.021). When the groups were compared in terms of inflammation, it was found that inflammation was less common in the SOT and LOT groups compared with the control group (SOT vs. control: P = 0.004 and LOT vs. control: P = 0.024), whereas inflammation was found to be significantly less in the SOT group compared with the LOT group (P = 0.008). In the histopathologic evaluation of epidural fibrosis, there was no significant difference between the SOT and LOT groups but less epidural fibrosis was observed in both groups compared to the control group (LOT vs. control: P = 0.037; SOT vs. control: P = 0.018). CONCLUSIONS: Medical ozone therapy may be an alternative method that can be used effectively and safely in the prevention of epidural fibrosis after laminectomy.


Subject(s)
Inflammation , Vascular Endothelial Growth Factor A , Rats , Male , Animals , Rats, Sprague-Dawley , Fibrosis , Inflammation/pathology , Wound Healing , Laminectomy/methods , Epidural Space/pathology
3.
J Burn Care Res ; 42(6): 1243-1253, 2021 11 24.
Article in English | MEDLINE | ID: mdl-34136919

ABSTRACT

Burns are one of the most severe traumas, causing coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burns may affect rates of patient survival and reduce complications. We studied the effects of subcutaneous ozone injection on second-degree burn wounds in an animal model. For this study, 72 Sprague-Dawley male rats were divided randomly into the following three groups: control group, silver sulfadiazine group, and ozone group; each group was then divided randomly into two subgroups (day 7 or day 14 examination and euthanized). Superficial partial-thickness burns were created on the lower back. In the control group, subcutaneous 0.9% serum saline was injected daily into the burn area. In the silver sulfadiazine group, burns were dressed daily with silver sulfadiazine. In the ozone group, subcutaneous ozone was injected daily into the burn area. We performed tissue hydroxyproline level measurements and histopathological evaluations. When groups were compared in terms of weight change, no significant difference was found between day 7 and day 14. With regard to tissue hydroxyproline levels, the ozone group had significantly higher levels on both days 7 and 14 (P < .001). In histopathological evaluations, we determined that wound healing in the ozone group was significantly higher than in the other groups. We found that subcutaneous ozone therapy was more effective than silver sulfadiazine in the healing process of second-degree burn wounds and could be safely used in the treatment of burn wounds.


Subject(s)
Burns/therapy , Hydrotherapy/methods , Ozone/therapeutic use , Therapies, Investigational , Administration, Topical , Animals , Male , Rats , Rats, Sprague-Dawley , Treatment Outcome , Wound Healing/drug effects
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