Neural encoding of musical expectations in a non-human primate.

The appreciation of music is a universal trait of humankind.1,2,3 Evidence supporting this notion includes the ubiquity of music across cultures4,5,6,7 and the natural predisposition toward music that humans display early in development.8,9,10 Are we musical animals because of species-specific predispositions? This question cannot be answered by relying on cross-cultural or developmental studies alone, as these cannot rule out enculturation.11 Instead, it calls for cross-species experiments testing whether homologous neural mechanisms underlying music perception are present in non-human primates. We present music to two rhesus monkeys, reared without musical exposure, while recording electroencephalography (EEG) and pupillometry. Monkeys exhibit higher engagement and neural encoding of expectations based on the previously seeded musical context when passively listening to real music as opposed to shuffled controls. We then compare human and monkey neural responses to the same stimuli and find a species-dependent contribution of two fundamental musical features-pitch and timing12-in generating expectations: while timing- and pitch-based expectations13 are similarly weighted in humans, monkeys rely on timing rather than pitch. Together, these results shed light on the phylogeny of music perception. They highlight monkeys' capacity for processing temporal structures beyond plain acoustic processing, and they identify a species-dependent contribution of time- and pitch-related features to the neural encoding of musical expectations.

Corticocortical Systems Underlying High-Order Motor Control.

Cortical networks are characterized by the origin, destination, and reciprocity of their connections, as well as by the diameter, conduction velocity, and synaptic efficacy of their axons. The network formed by parietal and frontal areas lies at the core of cognitive-motor control because the outflow of parietofrontal signaling is conveyed to the subcortical centers and spinal cord through different parallel pathways, whose orchestration determines, not only when and how movements will be generated, but also the nature of forthcoming actions. Despite intensive studies over the last 50 years, the role of corticocortical connections in motor control and the principles whereby selected cortical networks are recruited by different task demands remain elusive. Furthermore, the synaptic integration of different cortical signals, their modulation by transthalamic loops, and the effects of conduction delays remain challenging questions that must be tackled to understand the dynamical aspects of parietofrontal operations. In this article, we evaluate results from nonhuman primate and selected rodent experiments to offer a viewpoint on how corticocortical systems contribute to learning and producing skilled actions. Addressing this subject is not only of scientific interest but also essential for interpreting the devastating consequences for motor control of lesions at different nodes of this integrated circuit. In humans, the study of corticocortical motor networks is currently based on MRI-related methods, such as resting-state connectivity and diffusion tract-tracing, which both need to be contrasted with histological studies in nonhuman primates.