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Therapeutic Methods and Therapies TCIM
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Pak J Pharm Sci ; 29(5): 1541-1544, 2016 Sep.
Article in English | MEDLINE | ID: mdl-27731810

ABSTRACT

The present study demonstrates the biological study of Ficus carica fruit. Methanolic extract of plant fruit was prepared and evaporated under reduced pressure by rota vapor and n- hexane, Chloroform, ethyl acetate and n-butanol soluble fractions were prepared separately from crude methanolic extract. These fractions were then screened for acetyl cholinesterase, butryl cholinesterase and lipoxygenase activities. n-butanol soluble fraction showed significant antiacetylcholinesterase activity (78.55±0.76%) with IC50 of 55.8±0.37µg/ml, ethyl acetate soluble fraction showed significant anti-butrylcholinesterase activity (70.35±0.85%) with IC50 of 276.5±0.64µg/ml and significant antilipoxygenase activity was shown by ethyl acetate soluble fraction (62.52±0.26%) with IC50 of 380±0.08µg/ml.


Subject(s)
Cholinesterase Inhibitors/pharmacology , Ficus/chemistry , Lipoxygenase Inhibitors/pharmacology , Chemical Fractionation , Cholinesterase Inhibitors/isolation & purification , Fruit , Lipoxygenase Inhibitors/isolation & purification , Phytotherapy , Plants, Medicinal , Solvents/chemistry
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