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Ann Endocrinol (Paris) ; 73(3): 216-21, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22497798

ABSTRACT

The primary intracranial development of olfactory neuroblastomas, outside olfactory epithelium, is rare. We report a case of primary sellar neuroblastoma without any aggressive histopathological features, managed solely surgically without adjuvant therapy, with good outcomes at 3 years. Primary sellar neuroblastomas mostly occur in women in the 4th decade with a context of a non-secreting pituitary tumour. Diagnosis is made on histopathological examination (small cells, fibrillary intercellular background, strong immunoreactivity for neurons markers, negative immunoreactivity for anterior pituitary hormones). Management is based on surgery. Adjuvant treatment is not consensual, largely depends on patient's conditions and aggressive histopathological features.


Subject(s)
Esthesioneuroblastoma, Olfactory/diagnosis , Hypophysectomy , Inappropriate ADH Syndrome/etiology , Sella Turcica , Supratentorial Neoplasms/diagnosis , 3-Iodobenzylguanidine , Adenoma/diagnosis , Adult , Amenorrhea/etiology , Biomarkers, Tumor , Diagnosis, Differential , Esthesioneuroblastoma, Olfactory/chemistry , Esthesioneuroblastoma, Olfactory/complications , Esthesioneuroblastoma, Olfactory/pathology , Esthesioneuroblastoma, Olfactory/surgery , Female , Humans , Hyperprolactinemia/etiology , Iodine Radioisotopes , Magnetic Resonance Imaging , Neoplasm Proteins/analysis , Pituitary Neoplasms/diagnosis , Prognosis , Radiopharmaceuticals , Remission Induction , Supratentorial Neoplasms/chemistry , Supratentorial Neoplasms/complications , Supratentorial Neoplasms/pathology , Supratentorial Neoplasms/surgery , Vision Disorders/etiology , Whole Body Imaging
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