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J Clin Pharm Ther ; 46(1): 208-211, 2021 Feb.
Article in English | MEDLINE | ID: mdl-31913531

ABSTRACT

WHAT IS KNOWN AND OBJECTIVE: Thyrotoxic periodic paralysis (TPP) with hypokalaemia is a rare acute phenomenon. Reports of the use of high-dose non-selective ß-blockers describe symptom resolution, but often administration does not occur promptly enough in the treatment course and patients may experience overcorrection and hyperkalaemia. CASE DESCRIPTION: A 37-year-old Hispanic male developed TPP. Patient was successfully treated with low-dose oral propranolol and potassium supplementation with no overcorrection. WHAT IS NEW AND CONCLUSION: Delay in the administration of non-selective ß-blockers may lead to overcorrection of potassium with exogenous supplementation. Low-dose propranolol administered in the Emergency Department was successful in preventing overcorrection of potassium.


Subject(s)
Anti-Arrhythmia Agents/administration & dosage , Hypokalemia/diagnosis , Paralysis/diagnosis , Propranolol/administration & dosage , Thyroid Crisis/diagnosis , Administration, Oral , Adult , Diagnosis, Differential , Emergency Service, Hospital , Humans , Hypokalemia/complications , Hypokalemia/drug therapy , Male , Paralysis/complications , Paralysis/drug therapy , Thyroid Crisis/complications , Thyroid Crisis/drug therapy
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