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J Eur Acad Dermatol Venereol ; 16(4): 393-6, 2002 Jul.
Article in English | MEDLINE | ID: mdl-12224701

ABSTRACT

We report three patients presented with clinical features of Ofuji's papuloerythroderma (pruritic erythematous papules and extensive erythema sparing all skin folds), however, showing histopathological findings of mycosis fungoides (Pautrier's microabscess, haloed lymphocytes, disproportionate epidermotropism, and wiry collagen bundles). One case was associated with plaque stage of mycosis fungoides and follicular mucinosis. T-cell receptor (TCR) gene rearrangement analysis in the lesional skin tissue demonstrated rearrangement of the gamma chain in all cases. HTLV-1 serology was negative for two patients who conducted HTLV-1 test. We think that Ofuji's papuloerythroderma might be a variant of early mycosis fungoides rather than secondary skin manifestations to certain cutaneous inflammatory diseases.


Subject(s)
Dermatitis, Exfoliative/pathology , Mycosis Fungoides/pathology , Skin Diseases, Papulosquamous/pathology , Skin Neoplasms/pathology , Aged , Biopsy, Needle , Dermatitis, Exfoliative/diagnosis , Dermatitis, Exfoliative/drug therapy , Diagnosis, Differential , Follow-Up Studies , Humans , Immunohistochemistry , Male , Middle Aged , Mycosis Fungoides/diagnosis , Mycosis Fungoides/drug therapy , PUVA Therapy , Skin Diseases, Papulosquamous/diagnosis , Skin Diseases, Papulosquamous/drug therapy , Skin Neoplasms/diagnosis , Skin Neoplasms/drug therapy , Treatment Outcome
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