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Nat Clin Pract Urol ; 5(7): 403-7, 2008 Jul.
Article in English | MEDLINE | ID: mdl-18604226

ABSTRACT

BACKGROUND: A 71-year-old woman was referred to a surgical oncology clinic after CT raised suspicion for a bladder neoplasm. She had previously undergone right hemicolectomy and received adjuvant chemotherapy for pT3N1MX cancer of the cecum. A retroperitoneal recurrence had been deemed unsuitable for surgical resection, and had instead been treated with chemoradiation therapy. Follow-up CT raised suspicion for a possible bladder neoplasm. INVESTIGATIONS: CT, physical examination, urinalysis, cystoscopy with biopsy, pathological analysis and immunohistochemical analysis. DIAGNOSIS: Adenocarcinoma of the cecum metastatic to the bladder. MANAGEMENT: The patient underwent open bladder resection with total excision of the neoplasm and was administered adjuvant chemotherapy consisting of irinotecan and cetuximab. Subsequent recurrences at the same site were treated with transurethral resection, while chemotherapy was still in progress. At 7 months' follow-up, the patient remained alive, with no evidence of further recurrence.


Subject(s)
Adenocarcinoma/pathology , Cecal Neoplasms/pathology , Neoplasm Recurrence, Local/secondary , Urinary Bladder Neoplasms/secondary , Adenocarcinoma/diagnostic imaging , Adenocarcinoma/drug therapy , Adenocarcinoma/metabolism , Adenocarcinoma/surgery , Aged , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Humanized , Antimetabolites, Antineoplastic/therapeutic use , Antineoplastic Agents, Phytogenic/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Camptothecin/analogs & derivatives , Camptothecin/therapeutic use , Cecal Neoplasms/drug therapy , Cecal Neoplasms/metabolism , Cecal Neoplasms/surgery , Cetuximab , Chemotherapy, Adjuvant , Colectomy , Female , Fluorouracil/therapeutic use , Humans , Immunohistochemistry , Irinotecan , Leucovorin/therapeutic use , Neoplasm Invasiveness , Neoplasm Recurrence, Local/drug therapy , Neoplasm Recurrence, Local/surgery , Organoplatinum Compounds/therapeutic use , Quinazolines/therapeutic use , Retroperitoneal Neoplasms/pathology , Retroperitoneal Neoplasms/secondary , Sacrum/pathology , Thiophenes/therapeutic use , Tomography, X-Ray Computed , Urinary Bladder Neoplasms/diagnostic imaging , Urinary Bladder Neoplasms/drug therapy , Urinary Bladder Neoplasms/metabolism , Urinary Bladder Neoplasms/surgery
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