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Therapeutic Methods and Therapies TCIM
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BMC Nephrol ; 19(1): 379, 2018 12 27.
Article in English | MEDLINE | ID: mdl-30591031

ABSTRACT

BACKGROUND: The prevalence of cognitive disorders in hemodialysis patients is twice as high as the general population, while these disorders often are undiagnosed. Timely prevention and treatment can improve their personal and social functions. Aim of study was determined the effect of Valerian on cognitive disorders and electroencephalography (EGG) in hemodialysis patients. METHODS: This crossover, double-blind clinical trial was conducted on 39 hemodialysis patients. The patients were randomly divided into two groups. Group A (n = 19) took Valerian capsules and Group B (n = 20) received placebo capsules 60 min before bedtime for one month. The type of treatment was replaced between the two groups after a one-month wash-out. The Mini Mental State Examination (MMSE) questionnaire was completed and EGG was performed before and after intervention in both periods. RESULTS: The cognitive scores of the Group valerian were increased significantly in the first (p = 0.003) and the second (p = 0.005) periods. In addition, the mean increase in the cognitive scores in the Group valerian was significant in the first (p = 0.028) and the second periods (p = 0.030). However, the changes in EGG showed no significant difference before and after intervention in two groups. CONCLUSION: The findings of this study indicated that valerian could be effective and significantly improve patients' cognitive status; however, no significant changes were observed in the electroencephalography of the hemodialysis patients. TRIAL REGISTRATION: IRCT201606076318N7 -2016-06-17.


Subject(s)
Cognition Disorders/drug therapy , Electroencephalography/drug effects , Phytotherapy , Plant Extracts/therapeutic use , Valerian , Adult , Aged , Aged, 80 and over , Cognition Disorders/etiology , Cross-Over Studies , Double-Blind Method , Female , Humans , Male , Mental Status and Dementia Tests , Middle Aged , Plant Extracts/pharmacology , Renal Dialysis/adverse effects , Renal Insufficiency, Chronic/therapy
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