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Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata.

Buchanan, Malcolm S; Carroll, Anthony R; Edser, Annette; Sykes, Melissa; Fechner, Gregory A; Forster, Paul I; Guymer, Gordon P; Quinn, Ronald J.

Bioorg Med Chem Lett ; 18(4): 1495-7, 2008 Feb 15.

Article in English | MEDLINE | ID: mdl-18222087

ABSTRACT

A new natural product, lysianadioic acid, was isolated from the plant Lysiana subfalcata as a carboxypeptidase B (CPB) inhibitor. It is a potent inhibitor of CPB with an IC(50) of 0.36 microM. This is the first known example of a small molecule CPB inhibitor isolated from plant origin. Its structure was determined by NMR spectroscopy.

Subject(s)

Arginine/analogs & derivatives , Carboxypeptidase B/antagonists & inhibitors , Guanidines/chemistry , Guanidines/pharmacology , Loranthaceae/chemistry , Protease Inhibitors/chemistry , Protease Inhibitors/pharmacology , Succinates/chemistry , Succinates/pharmacology , Guanidines/isolation & purification , Nuclear Magnetic Resonance, Biomolecular , Plant Extracts/chemistry , Plant Extracts/isolation & purification , Plant Extracts/pharmacology , Protease Inhibitors/isolation & purification , Succinates/isolation & purification

ABSTRACT

Subject(s)

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