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Bioorg Med Chem Lett
; 18(4): 1495-7, 2008 Feb 15.
Article
in English
| MEDLINE
| ID: mdl-18222087
ABSTRACT
A new natural product, lysianadioic acid, was isolated from the plant Lysiana subfalcata as a carboxypeptidase B (CPB) inhibitor. It is a potent inhibitor of CPB with an IC(50) of 0.36 microM. This is the first known example of a small molecule CPB inhibitor isolated from plant origin. Its structure was determined by NMR spectroscopy.