1.
Org Biomol Chem
; 12(31): 5898-904, 2014 Aug 21.
Article
in English
| MEDLINE
| ID: mdl-24984102
ABSTRACT
The synthesis of a small library of (pyrrolidin-2-yl)triazoles via copper catalysed cycloaddition of an alkynyl iminocyclopentitol and a set of commercial and synthetic azides has been achieved. The in situ screening for the activity towards α-fucosidase of the resulting triazoles has allowed the identification of one of the most potent and selective pyrrolidine derived inhibitors of this enzyme (Ki = 4 nM).