Risk or benefit? Side effects of caffeine supplementation in sport: a systematic review.

PURPOSE: The aim of this study was to systematically review evidence on the prevalence and magnitude of side effects associated with caffeine supplementation in athletes. METHODS: Systematic searches through the PubMed, VHL, Scopus, and Web of Science databases were conducted according to the PRISMA guidelines. Peer-reviewed articles written in English that reported the prevalence/percentage or magnitude/effect size of side effects after caffeine supplementation in athletes in a sports context were included. Studies were grouped by the dose of caffeine administered as follows: low = ≤ 3.0 mg/kg; moderate = from 3.1 to 6.0 mg/kg; high = ≥ 6.1 mg/kg. The magnitude of the side effects was calculated with effect sizes. RESULTS: The search retrieved 25 studies that met the inclusion/exclusion criteria with a pooled sample of 421 participants. The supplementation with caffeine produced a higher prevalence or magnitude of all side effects under investigation when compared to placebo/control situations. The prevalence (magnitude) was between 6 and 34% (ES between 0.13 and 1.11) for low doses of caffeine, between 0 and 34% (ES between -0.13 and 1.20) for moderate doses of caffeine, and between 8 and 83% (ES between 0.04 and 1.52) with high doses of caffeine. The presence of tachycardia/heart palpitations and the negative effects on sleep onset had the highest prevalence and magnitude, in athletes using supplementation with caffeine. CONCLUSION: In summary, caffeine supplementation in the doses habitually used to enhance physical performance produces several side effects, both after exercise and at least 24 h after the ingestion. However, the prevalence and magnitude of side effects with high doses of caffeine were habitually higher than with low doses of caffeine. From a practical perspective, using ~3.0 mg/kg of caffeine may be the dose of choice to obtain the ergogenic benefits of caffeine with the lowest prevalence and magnitude of side effects.

Preliminary Research towards Acute Effects of Different Doses of Caffeine on Strength-Power Performance in Highly Trained Judo Athletes.

Although several previous studies examined the effect of pre-exercise caffeine ingestion on judo-specific performance, the optimal dose of caffeine to maximise the ergogenic effects for judoka is not clear. The main purpose of this study was to analyse the effects of oral administration of 3 and 6 mg/kg of caffeine on a battery of physical tests associated with judo performance. Ten highly trained national-level judoka (6 men and 4 women, age: 24.1 ± 4.7 years, body mass: 73.4 ± 12.9 kg, 15.1 ± 5.2 years of judo training experience, 2.6 mg/kg/day of habitual caffeine intake) participated in a randomized, crossover, placebo-controlled and double-blind experiment. Each judoka performed three identical experimental sessions after: (a) ingestion of 3 mg/kg of caffeine (CAF-3); (b) ingestion of 6 mg/kg of caffeine (CAF-6); (c) ingestion of a placebo (PLAC). After 60 min for substance absorption, participants performed the following tests: (a) bench press exercise with 50% of the load representing one-repetition maximum (1RM), including three sets of three repetitions; (b) bench pull exercise with 50% of 1RM including three sets of three repetitions; (c) countermovement jump; (d) maximal isometric handgrip strength test; (e) dynamic and isometric versions of the Judogi Grip Strength Test. In comparison with PLAC, the ingestion of CAF-3 and CAF-6 increased peak bar velocity in the bench press exercise (1.27 ± 0.11 vs. 1.34 ± 0.13 and 1.34 ± 0.15 m/s, respectively; p < 0.01) and mean bar velocity in the bench pull exercise (1.03 ± 0.15 vs. 1.13 ± 0.13 and 1.17 ± 0.15 m/s; p < 0.05). Only CAF-6 increased mean bar velocity in the bench press exercise when compared with PLAC (0.96 ± 0.09 vs. 1.02 ± 0.11 m/s; p < 0.05). Both CAF-3 and CAF-6 significantly increased the number of repetitions in the Judogi Grip Strength Test (17 ± 10 vs. 20 ± 10 and 20 ± 10 repetitions; p < 0.05). There were no differences between PLAC and caffeine doses in the remaining tests. The pre-exercise ingestion of 3 and 6 mg/kg of caffeine effectively obtained meaningful improvements in several aspects associated with judo performance. From a practical viewpoint, the selection between 3 or 6 mg/kg of caffeine may depend on previously tested individual responses during simulated competition.

Effects of acute ingestion of caffeinated chewing gum on performance in elite judo athletes.

PURPOSE: Previous investigations have found positive effects of acute ingestion of capsules containing 4-to-9 mg of caffeine per kg of body mass on several aspects of judo performance. However, no previous investigation has tested the effectiveness of caffeinated chewing gum as the form of caffeine administration for judoists. The main goal of this study was to assess the effect of acute ingestion of a caffeinated chewing gum on the results of the special judo fitness test (SJFT). METHODS: Nine male elite judo athletes of the Polish national team (23.7 ± 4.4 years, body mass: 73.5 ± 7.4 kg) participated in a randomized, crossover, placebo-controlled and double-blind experiment. Participants were moderate caffeine consumers (3.1 mg/kg/day). Each athlete performed three identical experimental sessions after: (a) ingestion of two non-caffeinated chewing gums (P + P); (b) a caffeinated chewing gum and a placebo chewing gum (C + P; ~2.7 mg/kg); (c) two caffeinated chewing gums (C + C; ~5.4 mg/kg). Each gum was ingested 15 min before performing two Special Judo Fitness Test (SJFT) which were separated by 4 min of combat activity. RESULTS: The total number of throws was not different between P + P, C + P, and C + C (59.66 ± 4.15, 62.22 ± 4.32, 60.22 ± 4.08 throws, respectively; p = 0.41). A two-way repeated measures ANOVA indicated no significant substance × time interaction effect as well as no main effect of caffeine for SJFT performance, SJFT index, blood lactate concentration, heart rate or rating of perceived exertion. CONCLUSIONS: The results of the current study indicate that the use of caffeinated chewing gum in a dose up to 5.4 mg/kg of caffeine did not increase performance during repeated SJFTs.