[Mutagenic effects of asbestos modified by association with ethanol, coffee and tobacco tar]. / Modifikatsiia mutagennogo deistviia asbesta pri sochetanii s étanolom, kofe i kuritel'noi smoloi.

The study covered possible modification of mutagenic action of asbestos in combination with widespread agents--ethanol, coffee extractive and fumigating resin. Such modifying effects as antagonism, synergism were revealed as well as an independent action. An attempt was made to extrapolate the obtained data to human exposure to asbestos.

[Cellular immunity and enzyme activity of xenobiotic metabolism in the lymphocytes of normal minipigs and in alcohol and anabol exposures]. / Kletochnyi immunitet i aktivnost' fermentov metabolizma ksenobiotikov v limfotsitakh u mini-svinei v norme i pri deistvii alkogolia i anabola.

Immunological indices and activity of xenobiotic metabolism enzymes in lymphocytes were studied on minipigs under normal conditions, under conditions of chronic alcoholic intoxication and after administration of anabol (an immunomodulator) to normal healthy animals and to animals with alcohol intoxication. Age-related differences with respect to the number of T-lymphocytes and activity of lymphocyte glutathione S-transferase were observed in the normal animals, the other indices such as activity of natural killer cells, K-cells, blast cell transformation with concanavalin A and activity of cytochrome c-reductase being independent of the age. Administration of anabol to healthy animals did not alter their immunoenzymatic status. Chronic alcohol intoxication was accompanied by development of secondary immune deficiency characterized by lower immunological indices and lower activity of xenobiotic metabolism enzymes in lymphocytes. Daily exposure to 0.8 g of anabol for 12 days at this background resulted in normalization of the above indices.

[Micronucleus test as a short-term assay for detecting the potential carcinogenicity of different groups of chemical compounds]. / Mikroiadernyi test kak kratkosrochnyi metod vyiavleniia potentsial'noi onkogennosti razlichnykh grupp khimicheskikh veshchestv.

Certain theoretical aspects of the method, the normal level of micronuclei in polychromatic erythrocytes of bone marrow cells in different animals species, the data obtained for the different types of chemical compounds are analyzed as well as the possibility of obtaining false-negative and false-positive results. This method is found to be very promising and needs further development in the near future.