Construction of a human body model for acupuncture and moxibustion treatment by colored Petri nets.

Acupuncture and moxibustion treatment has been widely spread all over the world because it has few side effects and is effective for ahead sick and incurable disease. However, the treatment is often performed empirically and clinically, and the mechanism and process of the treatment are not yet scientifically elucidated. Therefore, it is required to establish objective and unified research methods and evaluation criteria that incorporate modern Western medicine and scientific and technological viewpoints. In this paper, a human body model is constructed, which includes the internal organs and the meridians for acupuncture and moxibustion treatment based on traditional Chinese medicine using colored Petri nets. This model aims at expressing the relationship between acupoints and internal organs realistically and accurately in acupuncture and moxibustion treatment, and leading to realization of an objective analysis method of the mechanism and process of acupuncture and moxibustion treatment. Firstly, the calculation of the acupoints' efficacy on internal organs is discussed, and measurement equations and model construction methods are proposed. Next, an interface is established as a bridge to connect the internal organs and the meridians with acupoints. By Java language, a simulation system is developed based on the proposed Petri net model. Finally, simulations of acupuncture and moxibustion treatment are performed to verify the validity of model.

Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species.

To identify candidate bacteria associated with aging, we performed fecal microbiota sequencing in young, middle-aged and older adults, and found lower Bifidobacterium adolescentis abundance in older individuals aged ≥60 years. Dietary supplementation of B. adolescentis improved osteoporosis and neurodegeneration in a mouse model of premature aging (Terc-/-) and increased healthspan and lifespan in Drosophila melanogaster and Caenorhabditis elegans. B. adolescentis supplementation increased the activity of the catalase (CAT) enzyme in skeletal muscle and brain tissue from Terc-/- mice, and suppressed cellular senescence in mouse embryonic fibroblasts. Transgenic deletion of catalase (ctl-2) in C. elegans abolished the effects of B. adolescentis on the lifespan and healthspan. B. adolescentis feeding also led to changes in oxidative stress-associated metabolites in Terc-/- mouse feces. These results suggest a role for B. adolescentis in improving the healthspan and lifespan through the regulation of CAT activity and host metabolism.