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Assignment of the human gene for receptor-type protein tyrosine phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and identification of an intragenic genetic marker.

van den Maagdenberg, A M; Olde Weghuis, D; Rijss, J; van de Wetering, R A; Wieringa, B; Geurts van Kessel, A; Hendriks, W J.

Cytogenet Cell Genet ; 73(1-2): 145-8, 1996.

Article in English | MEDLINE | ID: mdl-8646884

ABSTRACT

Using a mouse protein tyrosine phosphatase cDNA fragment as a probe, cosmid clones containing segments of the human IA-2 PTPase gene (PTPRN) were isolated. The gene was assigned to chromosome region 2q35 --> q36.1 by fluorescence in situ hybridization. In an intronic region of the IA-2 gene a polymorphic microsatellite sequence was found, which will be useful as a genetic marker for the 2q35 --> q36 region.

Subject(s)

Chromosomes, Human, Pair 2/genetics , Genetic Markers , Isoenzymes/genetics , Membrane Proteins/genetics , Protein Tyrosine Phosphatases/genetics , Amino Acid Sequence , Animals , Autoantigens , Base Sequence , Cosmids/genetics , DNA, Complementary/genetics , DNA, Satellite/genetics , Genes , Humans , In Situ Hybridization, Fluorescence , Mice , Molecular Sequence Data , Polymorphism, Genetic , Receptor-Like Protein Tyrosine Phosphatases, Class 8 , Species Specificity

Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization.

van den Maagdenberg, A M; van den Hurk, H H; Weghuis, D; Wieringa, B; Geurts van Kessel, A; Hendriks, W J.

Genomics ; 30(1): 128-9, 1995 Nov 01.

Article in English | MEDLINE | ID: mdl-8595895

Subject(s)

Chromosomes, Human, Pair 10 , In Situ Hybridization, Fluorescence , Protein Tyrosine Phosphatases/genetics , Base Sequence , Cosmids , DNA, Complementary , Humans , Molecular Sequence Data , Polymerase Chain Reaction

ABSTRACT

Subject(s)

Subject(s)

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