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Therapeutic Methods and Therapies TCIM
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Phytochemistry ; 71(5-6): 682-7, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20181367

ABSTRACT

Thirty-six naturally occurring compounds, including four C(10)-acetylenic glycosides and a lignan, were isolated from the whole plants of Saussurea cordifolia. Their structures were elucidated by means of spectroscopic and chemical methods to be 4,6-decadiyne-1-O-beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside (1), 4,6-decadiyne-1-O-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (2), (8E)-decaene-4, 6-diyn-1-O-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (3), (8Z)-decaene-4,6-diyn-1-O-beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside (4), and (2R,3S,4S)-4-(4-hydroxy-3-methoxybenzyl)-2-(5-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-tetrahydrofuran-3-ol (5).


Subject(s)
Alkynes/isolation & purification , Antineoplastic Agents, Phytogenic/isolation & purification , Breast Neoplasms/drug therapy , Glycosides/isolation & purification , Lignans/isolation & purification , Plant Extracts/chemistry , Saussurea/chemistry , Alkynes/pharmacology , Alkynes/therapeutic use , Antineoplastic Agents, Phytogenic/pharmacology , Antineoplastic Agents, Phytogenic/therapeutic use , Cell Line, Tumor , Female , Glycosides/pharmacology , Glycosides/therapeutic use , Humans , Lignans/pharmacology , Lignans/therapeutic use , Molecular Structure , Phytotherapy , Plant Extracts/pharmacology , Plant Extracts/therapeutic use
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