The role of angelica injection on P-selectin and anti-cardiolipin antibodies in acute pulmonary embolism rats / 中国应用生理学杂志

<p><b>OBJECTIVE</b>To study the effect of Chinese medicine, Angelica, injection on the expression of P-, E-selectin and anti-cardiolipin antibody in acute pulmonary embolism rats.</p><p><b>METHODS</b>SD rats were randomly divided into 3 groups: normal control group(Group N), thromboembolism group (Group T), and treatment group of thromboembolism with angelica injection (Group TA). There were three time points in every group: 1 h, 4 h and 8 h. Plasma was detected by P-, with 4% paraformaldehyde, and paraffin embedded sections were detected by immunohistochemistry for P-, E-selectin and anti-cardiolipin antibodies.</p><p><b>RESULTS</b>With HE stain, the inflammatory cells in the lung of rats were relatively rare in every time point in normal control group. In group T and group TA, the inflammatory cells were increasing in every time point in comparison to group N (P < 0.05) and the inflammatory cells were increasing with time in group T. The data revealed that the plasmic level of P-, E-selectin was significantly higher than that in group T1, group T4, group T8 in comparison to the corresponding sub groups of group N (P < 0.05), while it was significantly lower than that in group TA1, group TA4, group TA8 in comparison to the corresponding sub groups of group T (P < 0.05); For the OD value of plasmic anti-cardiolipin antibodies (ACA), no significant difference was observed during was lower expressed by immunohistochemistry.</p><p><b>CONCLUSION</b>Acute pulmonary embolism can lead to infiltration of inflammatory cell in rat lungs. The lung inflammation of acute pulmonary embolism rats can be enhanced probably by the increased release of P-, E-selectin and anti-cardiolipin antibodies, and the enhanced inflammation promotes the release of a series of inflammatory mediators, which exacerbate the injury of lung. Angelica injection relieves the lung inflammation of acute pulmonary embolism rats possibly by inhibiting the expression of P-, E-selectin and anti-cardiolipin antibody, thus playing a role in reducing thrombogenesis.</p>

Clinical observation on acupoint catgut embedding therapy for treatment of ulcerative colitis / 中国针灸

<p><b>OBJECTIVE</b>To compare therapeutic effects of acupoint catgut embedding therapy and western medicine on ulcerative colitis.</p><p><b>METHODS</b>One hundred and sixteen cases of ulcerative colitis were randomly divided into a treatment group and a control group. The treatment group of 56 cases were treated with catgut embedding at Dachangshu (BL 25), Zusanli (ST 36), Shangjuxu (ST 37) and other points, and the control group with oral administration of salicylazosul-fapyridine, 4-6 g/day. The therapeutic effects and improvement of symptoms were evaluated by reexamination of endoscopy before and 4 weeks, 6-8 weeks after treatment in the two groups, and changes of stool property and abdominal pain were compared.</p><p><b>RESULTS</b>The short-term therapeutic effect and the long-term therapeutic effect of the treatment group were better than those of the control group.</p><p><b>CONCLUSION</b>Acupoint catgut embedding therapy has a better therapeutic effect on ulcerative colitis with less adverse reactions.</p>