[Progress of researches on the development of non-benzimidazoles for the treatment of echinococcosis].

The long-term use of benzimidazoles for the treatment of echinococcosis may cause multiple adverse reactions and low compliance. A search for novel agents, as an alternative of benzimidazoles, is therefore of great significance for the treatment of echinococcosis. This review focuses on the progress of researches on non-benzimidazoles for the clinical treatment of echinococcosis, including anti-parasitic agents, anti-proliferative agents and plant extracts, so as to provide insights into the further development of non-benzimidazoles.

[Quantitative analysis of 200 human tongue pictures].

Photoelectricity integration was applied to detect and analyse the colorimetric tongue pictures in 200 human beings. The results showed that among various tongue pictures there were evident differences in colorimetric features. This method could also assess the thickness of tongue coating, thus obtaining the colorimetric features including color of tongue proper, color of coating as well as thickness index in common tongue pictures. Therefore it might provide scientific basis for objective and quantitative assessment of tongue pictures in TCM.

[Simultaneous detection of the platelet aggregation and release in patients with cardio-cerebral vascular diseases associated with blood stasis and their clinical significance].

The authors determined the platelet aggregation(PA) activity respectively with electric impedance and photoelectric turbidimetry in patients with ischemic cardio-cerebral vascular diseases associated with blood stasis. The results showed the PA activities were elevated both in whole blood and plasma. Then, the authors detected simultaneously the PA activity and amount of post-aggregation beta-thromboglobulin(beta-TG) releasing and also in vivo amount of spontaneous plasma releasing of beta-TG with photoelectric turbidimetry and RIA methods with blood stasis. The results showed, during the acute phase of stroke, a high activated state of platelet existed, expressed as significant elevation both of the amount of beta-TG releasing of post-aggregation and plasma beta-TG level. However, no definite correlation between rate of PA and subsequent amount of beta-TG releasing was found, and detection of aggregation rate alone did not disclose the state of activation. As compared with the acute phase, during the recovery stage of stroke in which the clinical symptom of blood stasis was improved, the plasma beta-TG level declined significantly, however, was still higher than in normal controls; amount of releasing beta-TG was declining which denoted that the platelet functions were reducing then, but were still in a higher state of activation. These results suggested that there were changes both in number and quality of platelet in patients with blood stasis.

[Plasma tissue-type plasminogen activator and plasminogen activator inhibitor activities and their ratio in patients with ischemic stroke associated with stagnation of blood during various stages].

The studies showed that t-PA activity was elevated during the acute phase, remained elevated during the recovery stage and declined during the sequelar stage. Lowering of PAI activity was found during the acute phase, which was reversed during the recovery phase and remained significantly elevated during the sequelar stage compared with the controls (P less than 0.001), F test showed that both t-PA and PAI activities changed significantly during various stages (t-PA, P less than 0.01; PAI, P less than 0.001). Because of these changes, the ratio of PAI and t-PA fluctuated during different stages of the disease. This ratio decreased during the acute stage and came close to the normal levels during the recovery phase. The ratio, however, elevated abnormally during the sequelar stage, compared with healthy controls (P less than 0.05), In addition, the result of correlation test and linear regression analysis of serum t-PA and PAI activities in 54 cases showed a significant negative correlation (P less than 0.001) existed between t-PA and PAI activities. The balance of plasma t-PA and PAI activities have the function in maintaining the normal bloodstream in human body. In the process of disease, the abnormality of plasma t-PA and PAI activities may be the different pathological characteristics involved in this stagnation process. If coordinated with differentiation of syndrome in TCM, it may have the important significance to follow-up, and determine prognosis and early diagnosis for certain potential clinical stagnation of blood.