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Complementary Medicines
Therapeutic Methods and Therapies TCIM
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1.
J Perinatol ; 34(9): 720-2, 2014 Sep.
Article in English | MEDLINE | ID: mdl-25179384

ABSTRACT

Historically, congenital pulmonary lymphangiectasia (CPL) has had poor treatment outcomes despite aggressive therapy. There are recent reports of ethiodized oil (Lipiodol) lymphangiography successfully treating lymphatic leakage in adults. In this report, we describe two infants with CPL complicated by chylothoraces successfully treated by instillation of ethiodized oil into the lymphatic system. Congenital atresia of the thoracic duct was demonstrated on the lymphangiogram in both patients before treatment. Both patients have shown good short-term outcomes without supplemental oxygen or fat restricted diets at 9 months of age. Ethiodized oil lymphangiography represents a new treatment modality for some patients with CPL.


Subject(s)
Contrast Media/therapeutic use , Ethiodized Oil/therapeutic use , Lung Diseases/congenital , Lymphangiectasis/congenital , Lymphography , Embolization, Therapeutic , Female , Humans , Infant , Lung Diseases/diagnostic imaging , Lung Diseases/drug therapy , Lymphangiectasis/diagnostic imaging , Lymphangiectasis/drug therapy
2.
Science ; 341(6142): 175-9, 2013 Jul 12.
Article in English | MEDLINE | ID: mdl-23788733

ABSTRACT

Steroidal glycoalkaloids (SGAs) such as α-solanine found in solanaceous food plants--as, for example, potato--are antinutritional factors for humans. Comparative coexpression analysis between tomato and potato coupled with chemical profiling revealed an array of 10 genes that partake in SGA biosynthesis. We discovered that six of them exist as a cluster on chromosome 7, whereas an additional two are adjacent in a duplicated genomic region on chromosome 12. Following systematic functional analysis, we suggest a revised SGA biosynthetic pathway starting from cholesterol up to the tetrasaccharide moiety linked to the tomato SGA aglycone. Silencing GLYCOALKALOID METABOLISM 4 prevented accumulation of SGAs in potato tubers and tomato fruit. This may provide a means for removal of unsafe, antinutritional substances present in these widely used food crops.


Subject(s)
Crops, Agricultural/genetics , Multigene Family , Nutritive Value/genetics , Solanaceous Alkaloids/biosynthesis , Solanaceous Alkaloids/genetics , Solanum lycopersicum/genetics , Solanum tuberosum/genetics , Gene Expression Profiling , Gene Expression Regulation, Plant , Gene Silencing , Genes, Plant , Solanaceous Alkaloids/toxicity
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