ABSTRACT
We have already confirmed the effectiveness of the re-entrant resonant cavity applicator system with non-invasive experiments of heating cylindrical agar phantoms and computer simulations. This paper discusses the heating properties of the developed heating system with a human head model made of agar for brain tumor hyperthermia treatment. First, we present the results of heating a uniform agar head model with the developed heating system. In the experiments, the temperature rise at the center of the agar was about 8 degrees C, it was found that the center of the agar is heated to maximum temperature non-invasively. Second, we present the results of heating a non-uniform agar head model having an oral cavity and a nasal cavity. We found that the center of the agar can be heated to maximum temperature as well as uniform agar head model. From these results, it is confirmed that the possibility of effective hyperthermia for various types of deep-seated brain tumors.
Subject(s)
Brain Neoplasms/physiopathology , Brain Neoplasms/therapy , Brain/physiopathology , Brain/radiation effects , Catheter Ablation/methods , Hyperthermia, Induced/methods , Body Temperature/radiation effects , Catheter Ablation/instrumentation , Computer Simulation , Dose-Response Relationship, Radiation , Equipment Design , Equipment Failure Analysis , Hyperthermia, Induced/instrumentation , Models, Biological , Radiation Dosage , Reproducibility of Results , Sensitivity and Specificity , TransducersABSTRACT
In this paper, we have proposed a new heating method in which high frequency electric fields in a re-entrant type resonant cavity are used for the heating of deeply seated tumors. In this method, a human head is placed between the gap of the inner re-entrant cylinders, and is heated with electromagnetic fields stimulated in the cavity without contact between the surface of the human head and the applicator. Here, we proposed a new method to control the heating area. In this method, the resonant frequency inside the cavity was changed, then we use the TM010-like mode and the TM012-like mode from various types of the resonant frequency. First, the computer simulation results of electric and magnetic field patterns are presented. Second, a comparison of the heating properties of TM010-like mode and TM012-like mode are discussed. The heating area of the center of agar phantom is more concentrated by using TM012-like mode than that of using TM010-like mode. From these results, it is confirmed that the proposed method can be controlled to heat the various sizes of deep tumors.
Subject(s)
Brain Neoplasms/physiopathology , Brain Neoplasms/therapy , Hyperthermia, Induced/instrumentation , Models, Biological , Radiofrequency Therapy , Therapy, Computer-Assisted/methods , Transducers , Computer Simulation , Computer-Aided Design , Equipment Design , Equipment Failure Analysis , Finite Element Analysis , Hot Temperature , Humans , Hyperthermia, Induced/methods , Therapy, Computer-Assisted/instrumentationABSTRACT
This paper discusses a new method to control the heating area of a re-entrant resonant cavity applicator for brain tumor hyperthermia treatment non-invasively. We have already discussed about the effectiveness of a developed system with experiments of heating an agar phantom and computer simulations. Here, in order to heat a deep brain tumor, we propose the heating method of using several electromagnetic heating modes which are transverse magnetic (TM) modes. In this method, TM010-like and TM012-like modes obtained by selecting resonant frequencies can be used to heat the deep brain tumors. To control the heating area of the modes the agar phantom is used in the heating experiments by the developed system. From these results, we found that the heating area of the agar phantom by using TM012-like mode is about 50% of the heating area of TM010-like mode. It is found that the proposed heating system can be applicable to the hyperthermia treatment of brain tumors corresponding to the size and the position where it occurred.