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Objective: To analyze the effect of acupuncture versus hormone replacement therapy (HRT) for premature ovarian insufficiency (POI). Methods: China National Knowledge Infrastructure (CNKI), Wanfang Academic Journal Full-text Database (Wanfang), Chongqing VIP Database (CQVIP), China Biology Medicine Disc (CBM), Web of Science, Cochrane Library, PubMed, and Excerpta Medica Database (EMBASE) were searched up to January 31st, 2019 to identify randomized controlled trials (RCTs) evaluating the effect of acupuncture for POI. The primary outcome was the level of basal serum follicle- stimulating hormone (FSH). Secondary outcomes included serum levels of luteinizing hormone (LH), estradiol (E2) and anti-Müllerian hormone (AMH). Two authors extracted data independently and assessed the risk of bias and the methodological quality using the Cochrane's tool. Meta-analysis was conducted by RevMan version 5.3. Results: Eight eligible RCTs with a total of 496 POI patients were included in the meta-analysis. The pooled results showed that there was a significant reduction in the basal serum FSH level (MD=-5.82, 95%CI:-9.76 to -1.87, I2=82%, P=0.004) and a remarkable elevation in the basal E2 level (SMD=0.93, 95%CI: 0.34 to 1.52, I2=88%, P=0.002) in the acupuncture group when compared with the control. Subgroup analysis showed that compared with HRT, a significant decrease in the FSH level was observed in both acupuncture alone (MD=-4.53, 95%CI:-8.96 to -0.10, I2=73%, P=0.04) and acupuncture plus HRT (MD=-9.60, 95%CI:-17.60 to -1.61, I2=50%, P=0.02), while a remarkable elevation of E2 was only found in acupuncture plus HRT (SMD=1.43, 95%CI: 1.03 to 1.82, I2=0%, P<0.00001). There was no significant difference in the LH level between acupuncture and HRT (MD=-3.16, 95%CI:-9.41 to 3.10, I2=0%, P=0.32), only one trial reported AMH, and no significant difference was found between acupuncture and HRT. Conclusion: The present study indicated that acupuncture had an advantage over HRT in reducing serum FSH level and increasing serum E2 level in women with POI. However, evidence supporting the finding is limited due to the small sample size, potential methodological flaws and significant heterogeneity. Hence, this conclusion still needs to be verified by high-quality RCTs.
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Objective To observe the effects of electroacupuncture on the learning and memory ability and cerebral cortex inflammatory factor of rats with vascular cognitive impairment (VCI); To discuss the mechanism of electroacupuncture for preventing and treating VCI. Methods VCI rat models were made in microemboli injection through internal carotid artery method. The successful modeled rats were randomly divided into model group, positive medicine group and electroacupuncture group, and normal rats were taken as control group. Three days after rat models were established, the positive medicine group was given donepezil hydrochlorideby gavage, and electroacupuncture group was given electroacupuncture at "Baihui" and "Zusanli" acupoints. After treatment, the learning and memory ability was detected by Morris water maze test. The contents of TNF-α, IL-6 and IL-1β in rat brain tissue were detected by ELISA. Results The water maze results showed that with the increase of the number of training, the average escape latency of rats to find platform in positive medicine group and electroacupuncture group all had different degrees of shortening in positioning cruise experiment; in space exploration experiment, positive medicine group and electroacupuncture group to cross the platform area for the first time were significantly reduced compared with the model group; compared with the control group, the contents of TNF-α, IL-6 and IL-1β in the model group were increased significantly; compared with the model group, the contents of TNF-α, IL-6 and IL-β in postive medicine group and electroacupuncture group were decreased. Conclusion Electroacupuncture at "Baihui"and "Zusanli" acupoints can decrease the contents of TNF-α, IL-1 and IL-6 in the cortex of VCI rats, and improve the learning and memory ability of rats.
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In recent years, acupuncture has been used widely as an adjuvant treatment for the in vitro fertilization (IVF). " " published in on May 15, 2018, the research findings do not support the use of acupuncture to improve the rate of live births among the women undergoing IVF. In order to avoid the misunderstanding of the scholars at home and abroad for the clinical effects of acupuncture on IVF assistance, the authors put forward the doubts after the analysis from the following 3 aspects, including the acupuncture scheme, outcomes and result explanation. Additionally, the thinking and suggestions are proposed for the future development of the clinical trials of acupuncture IVF assistance in terms of selecting the proper participants, being abided by the standards of the evidence-based medicine, designing multi-acupuncture schemes and setting up the rational control, as well as conducting the overall analysis of the trial data.
Subject(s)
Female , Humans , Pregnancy , Acupuncture , American Medical Association , Embryo Transfer , Fertilization in Vitro , Live Birth , Pregnancy Rate , United StatesABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect and safety of acupuncture with regulating menstruation to promote pregnancy for diminished ovarian reverse (DOR).</p><p><b>METHODS</b>According to prospective case series, 46 patients were observed and finally 40 cases were included. The acupoints were ① Baihui (GV 20), Shenting (GV 24), Guanyuan (CV 4) and bilateral Benshen (GB 13), Huangshu (KI 16), Dahe (KI 12), Luanchao (Extra), Zusanli (ST 36), Sanyinjiao (SP 6), Taixi (KI 3), Taichong (LR 3) and ② bilateral Shenshu (BL 23) and Ciliao (BL 32). The points in the two groups were used alternately. Acupuncture was given for 3 courses, 12 times as a course and 3 times a week. Before and after treatment, and 3 months after treatment, follicle-stimulating hormone (FSH), follicle-stimulating hormone/luteinizing hormone (FSH/LH), estradiol (E), antral follicle count (AFC) and TCM symptom score were observed. The safety was evaluated.</p><p><b>RESULTS</b>Compared with before treatment, the levels of FSH, FSH/LH decreased, and the levels of Eand AFC increased after treatment and at follow-up (all<0.05). And the TCM symptom scores were significantly lower than those before treatment (both<0.05). The rate of pregnancy after treatment was 15% (6/40). There was no infection and organ injury.</p><p><b>CONCLUSION</b>Acupuncture with regulating menstruation to promote pregnancy can safely improve the ovarian reserve of patients with DOR.</p>
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Prof. ZHANG Jin began study on the acupuncture manipulation skills from 1950s, his study covered seven aspects. Based on the ancient texts of Instruction of Acupuncture Canon: Reinforcing and Reducing Methods (by DOU Han-Qing) and Qiong Yao Book and Acupuncture, twenty-four single manipulations were summarized. This paper introduces the basic theory and specific procedure and clinical applications for the manipulation methods, such as Xun-fa, She-fa, Pan-fa, Cuo-fa, Fei-fa etc.
Subject(s)
Humans , Acupuncture Therapy , History , Methods , China , History, 20th Century , History, 21st CenturyABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical therapeutic effect of combination of Source Point and Back-Shu Point on perimenopausal syndrome, and provide a new thought of therapy for perimenopausal syndrome.</p><p><b>METHODS</b>Eighty cases of perimenopausal syndrome were randomly divided into a combination of Source Point and Back-Shu Point group and a routine acupuncture group, 40 cases in each group. The combination of Source Point and Back-Shu Point group was treated with acupuncture at Taixi (KI 3), Taichong (LR 3), Taibai (SP 3), Sanyinjiao (SP 6), Shenshu (BL 23), Ganshu (BL 18), Pishu (BL 20), Guanyuan (CV 4); and the routine acupuncture group was treated with acupuncture at Baihui (GV 20), Guanyuan (CV 4), Shenshu (BL 23), Taixi (KI 3), San-yinjiao (SP 6). The Kupperman score and the changes of serum estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were observed before and after treatment in the two groups.</p><p><b>RESULTS</b>The total effective rate of 92.5% in the combination of Source Point and Back-Shu Point group was superior to 80.0% in the routine acupuncture group, with a significant difference (P < 0. 05); the Kupperman score of 24. 85 +/- 8.35 in the combination of Source Point and Back-Shu Point group was significantly decreased as compared with 35.38 +/- 9.83 in the routine acupuncture group (P < 0.05) after treatment; the contents of E2, FSH and LH in the combination of Source Point and Back-Shu Point group were significantly improved after treatment, and with a significant difference compared to the routine acupuncture group (P < 0.01, P < 0.05).</p><p><b>CONCLUSION</b>Combination of Source Point and Back-Shu Point has a benign regulation function for E2, FSH and LH, and can significantly improve the Kupperman score, is superior to routine acupuncture for perimenopausal syndrome.</p>
Subject(s)
Female , Humans , Middle Aged , Acupuncture , Methods , Acupuncture Points , Acupuncture Therapy , Methods , Estradiol , Blood , Follicle Stimulating Hormone , Blood , Luteinizing Hormone , Blood , Perimenopause , Blood , Syndrome , Treatment OutcomeABSTRACT
<p><b>OBJECTIVE</b>To observe therapeutic effect of acupuncture combined with rehabilitation therapy on poststroke shoulder-hand syndrome.</p><p><b>METHODS</b>One hundred and twenty cases of poststroke shoulder-hand syndrome were randomly divided into an acupuncture-rehabilitation group, an acupuncture group and a rehabilitation group, 40 cases in each group. The acupuncture-rehabilitation group were treated with acupuncture at Jianyu (LI 15), Jianqian, Jianliao (TE 14), etc. in combination with motor therapy (rehabilitation training), the acupuncture group with simple acupuncture therapy, and the rehabilitation group with simple motor therapy. Upper extremity motor function, pain, joint activity were used for assessment of therapeutic effects.</p><p><b>RESULTS</b>The total effective rate of 87.5% in the acupuncture-rehabilitation group was significantly better than 67.5% in the acupuncture group and 65.0% in the rehabilitation group (P<0.01); acupuncture combined with rehabilitation therapy could significantly improve upper limb motor function, pain and joint activity with very significant differences as compared with the acupuncture group and the rehabilitation group (P<0.01).</p><p><b>CONCLUSION</b>Acupuncture combined with rehabilitation therapy has a high cured rate and an obvious therapeutic effect on poststroke shoulder-hand syndrome.</p>
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Acupuncture Therapy , Medicine, Chinese Traditional , Reflex Sympathetic Dystrophy , Therapeutics , Stroke RehabilitationABSTRACT
<p><b>OBJECTIVE</b>To compare therapeutic effects of acupuncture with pushing manipulation and routine acupuncture on finger flexion in the patient of poststroke.</p><p><b>METHODS</b>Eighty cases were randomly divided into a group of acupuncture with pushing manipulation and a routine acupuncture group. Hegu (LI 4), Houxi (SI 3), Waiguan (TE 5) were selected in the both groups. For the group of acupuncture with pushing manipulation (n=42), after arrival of qi acupuncture with pushing manipulation was given, the needle was inserted forcedly downwards, heavily thrust and lightly lifted with the thumb forward and the index-finger backward, and the needle was retained for 30 min. For the routine acupuncture group, after arrival of qi the needle was retained for 30 min. The therapeutic effects were assessed by modified Ashworth spastic rating and activity of metacarpophalangeal articulations after treatment of 30 days and 60 days in the two groups.</p><p><b>RESULTS</b>The total effective rate of 81.0% in the group of acupuncture with pushing manipulation was significantly better than 57.9% in the routine acupuncture group (P<0.05); there was a significant or a very significant difference between the two groups in changes of the spastic degree and the activity of metacarpophalangeal articulations after treatment (P<0.05, P<0.01).</p><p><b>CONCLUSION</b>Acupuncture with pushing manipulation has a definite therapeutic effect on finger flexion in the patient of poststroke.</p>
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Acupuncture Therapy , Methods , Fingers , Medicine, Chinese Traditional , Muscle Spasticity , Therapeutics , Physical Therapy Modalities , Stroke RehabilitationABSTRACT
<p><b>OBJECTIVE</b>To develop an HPLC method for the determination of serum level of Crebanine (Cre) and study on the pharmacokinetics of Cre injection in rabbits.</p><p><b>METHOD</b>To sample blood serum from the rabbits' ears which were injected the Cre by 2.0 mg x kg(-1) at different time and use HPLC to determine the concentration of Cre in it, the pharmacokinetic parameters were accessed by the DAS software.</p><p><b>RESULT</b>Cre was fitted to a two compartment open pharmacokinetic model in rabbits. There was no signifiant difference between the male and female rabbits'pharmacokinetic by t-test. The mainly pharmacokinetic parameters were: t1/2alpha = (3. 246 +/-0.222) min, t1/2beta = (36.67+/-5.52) min, Cmax = (1.401 +/- 0.062) mg x L(-1), Vd = (5.928 +/- 0.877) L x kg(-1), Cl = (0. 051 +/-0.003) L x min(-1) x kg(-1).</p><p><b>CONCLUSION</b>This experiment can objectively show the pharmacokinetics regularity of Crebanine injection in rabbits. Crebanine injection was a speeding disposition drug (t1/2 <1 h) and disposed extensively and rapidly in rabbits.</p>
Subject(s)
Animals , Female , Male , Rabbits , Aporphines , Blood , Pharmacokinetics , Chromatography, High Pressure Liquid , Injections , Metabolic Clearance Rate , Plants, Medicinal , Chemistry , Stephania , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To observe clinical therapeutic effect of head point-through-point electroacupuncture on Parkinson's disease and the mechanism.</p><p><b>METHODS</b>Seventy-six cases of Parkinson's disease were randomly divided into a treatment group (n=37) treated with head point-through-point electroacupuncture and oral administration of madopa, and a control group (n=39) with only oral administration of madopa. Superoxide dismutase (SOD) and lipids peroxides (LPO) were determined before and after treatment.</p><p><b>RESULTS</b>The effective rate was 97.3% in the treatment group and 61.5% in the control group with a very significant difference between the two groups (P < 0.01). SOD activity and LPO content were significantly improved after treatment in the treatment group (P < 0.01), with a significant difference between the two groups (P < 0.01).</p><p><b>CONCLUSION</b>Head point-through-point electroacupuncture can improve SOD activity and LPO content in the body so as to cure Parkinson's disease.</p>