ABSTRACT
<p><b>OBJECTIVE</b>The study investigates the protective effect on liver of Danxionfang and its components.</p><p><b>METHOD</b>Mice are injected with CCl4 to establish liver injured model. ALT, AST, serum albumin, globulin in serum and SOD, MDA in liver and liver histological changes were measured to confirm the ability of protecting liver of Danxiongfang.</p><p><b>RESULT</b>The results show Danxiongfang can inhibit obviously the abnormal increase of ALT, AST in serum and MDA in liver, enhance SOD activity in liver, total protein, albumin, globulin in serum, and decrease liver pathological changes, which suggests Danxiongfang can protect injured liver induced by CCl4.</p><p><b>CONCLUSION</b>Danxiongfang showed powerful protective effect against liver damage induced by CCl4.</p>
Subject(s)
Animals , Female , Male , Mice , Alanine Transaminase , Blood , Aspartate Aminotransferases , Blood , Carbon Tetrachloride , Chemical and Drug Induced Liver Injury , Drug Combinations , Drugs, Chinese Herbal , Pharmacology , Ligusticum , Chemistry , Liver , Metabolism , Pathology , Liver Diseases , Blood , Malondialdehyde , Metabolism , Mice, Inbred ICR , Phytotherapy , Plants, Medicinal , Chemistry , Protective Agents , Pharmacology , Salvia miltiorrhiza , Chemistry , Superoxide Dismutase , MetabolismABSTRACT
The SARS epidemic is breaking out worldwide. To select suitable herbal drugs for clinical uses is important and urgent amongst the controversial treatment proposals. Nine pharmacological experimental models were used to evaluate the comprehensive efficacy of traditional Chinese remedies by cross validation in different institutes. Eight drugs were optimized for controlling different symptoms of SARS.