ABSTRACT
Soft tissues surrounding Brånemark titanium implants and single crystal sapphire implants were studied by conventional light- and transmission electron microscopy and by immunohistochemical markers for cytokeratin, protein S-100, Factor VIII and KP1. Histological sections of biopsies obtained from clinically healthy peri-implant mucosa were separated into a keratinized outer implant epithelium and an inner, non-keratinized epithelium, both immunoreactive towards cytokeratin. The inner implant epithelium terminated in a junctional epithelium, apically not a few cell layers thick. The cells adjacent to the implant showed a condensed cytoplasm, resembling hemidesmosomes. In the underlying connective tissue, rich in fibroblasts and factor VIII immunoreactive blood vessels, the bundles of collagen ran in different directions. S-100 immunoreactive nerve structures were more frequently found beneath the outer than the inner implant epithelium. Inflammatory cell infiltrates, some KP1 positive, were observed in the apical parts of the inner implant epithelium. S-100 positive Langerhans' cells were present mainly within the the outer implant epithelium. For the two implant systems, the techniques disclosed no qualitative structural differences in the adjacent soft tissues.
Subject(s)
Dental Implants , Osseointegration , Periodontium , Aluminum Oxide , Animals , Antigens, CD/analysis , Antigens, Differentiation, Myelomonocytic/analysis , Connective Tissue/pathology , Connective Tissue Cells , Epithelial Cells , Epithelium/pathology , Factor VIII/analysis , Humans , Immunohistochemistry , Keratins/analysis , Mice , Mouth Mucosa/anatomy & histology , Mouth Mucosa/pathology , Periodontium/anatomy & histology , Periodontium/blood supply , Periodontium/innervation , Periodontium/pathology , Periodontium/ultrastructure , Rabbits , S100 Proteins/analysis , TitaniumABSTRACT
71 healthy oral, throat and nasal carriers of Staphylococcus aureus undergoing surgical removal of impacted mandibular third molars were assigned to the following regimens. 40 patients received dicloxacillin 500 mg orally 60 min before the operation and then 500 mg dicloxacillin 3 times daily for 7 days and 31 patients no antibiotic. Oropharyngeal and nasal cultures were obtained from each patient before, during and after the operation. Dicloxacillin reduced the carrier rates significantly. No increase in in vitro antibiotic resistance was observed in the staphylococcal isolates obtained after therapy. Dicloxacillin was well tolerated and toxicity was not encountered in any patient.