ABSTRACT
To define the range of histio- and organotypical capacities of rat soft palatine and bronchial epithelia, and to elucidate the nature of the effect of neuroendocrine factors of hypothalamic paraventricular factors upon them, the experiments were conducted by co-culturing mucosal fragments of oral and pharyngeal surfaces of soft palate and bronchi with the paraventricular nuclei-containing hypothalamic fragments using in vivo F.M. Lazarenko method. Soft palatine and bronchial epithelia were found to have similar histoblastic properties. The stimulating effect of hypothalamic factors, released paraventricular nuclei, on the processes of regeneration of epithelia and of connective tissue was noted.
Subject(s)
Bronchi/ultrastructure , Neuropeptides/metabolism , Palate, Soft/ultrastructure , Regeneration , Animals , Bronchi/physiology , Bronchi/transplantation , Epithelium/physiology , Epithelium/transplantation , Epithelium/ultrastructure , Hypothalamus/metabolism , Male , Microscopy, Electron , Organ Culture Techniques/methods , Palate, Soft/physiology , Palate, Soft/transplantation , Paraventricular Hypothalamic Nucleus/metabolism , Rats , Transplantation, AutologousABSTRACT
The paper presents the results of light, atomic-force, and electron microscopic studies of prokaryotes (various Staphylococcus aureus strains) and eukaryotes (Rat digestive and respiratory cells and tissues) in in vivo and in vivo interactions. It is concluded that hypothalamic nonapeptides play a modulating role in the persistence and symbiotic relations in the bacterium-host system and regulate cellular and tissue homeostasis through reparative histogenesis.
Subject(s)
Eukaryotic Cells/metabolism , Eukaryotic Cells/microbiology , Hypothalamus/metabolism , Hypothalamus/microbiology , Oxytocin/metabolism , Staphylococcal Infections/microbiology , Animals , Male , RatsABSTRACT
The role of hypothalamic nonapeptides in the interaction of prokaryotic and eukaryotic cells was studied in the experimental setting. Nonapeptides were found to stimulate the adaptive and regenerative properties of eukaryotic cells and they are likely to have an antimicrobic effect on prokaryotic ones. The paper discusses the modulating role of nonapeptides in the establishment of symbiotic relations in the bacterial agent-host system.