ABSTRACT
The hepatoprotective potential of a herbal mixture was evaluated against CCl4 induced liver injury in Swiss albino mice. Liv 52, a commercially available polyherbal hepatoprotective drug was evaluated for comparison. The potential toxicity of the above herbal hepatoprotective agents was also compared. It was observed that there was a reduction in the enzyme biomarkers (Aspartate and Alanine Transaminase) of liver injury in the herbal mixture treated groups, which was similar to the reduction initiated by Liv 52. An increase in glutathione was observed in the herbal mixture treated groups and it was assumed that the herbal mixture protects the liver by virtue of its antioxidant nature along with high regeneration initiation potential. From the study it is also concluded that the herbal mixture is safer than Liv 52.
Subject(s)
Liver Diseases/drug therapy , Phytotherapy , Plant Extracts/therapeutic use , Protective Agents/therapeutic use , Alanine Transaminase/blood , Alkaline Phosphatase/metabolism , Animals , Aspartate Aminotransferases/blood , Blood Glucose/analysis , Blood Urea Nitrogen , Carbon Tetrachloride , Chemical and Drug Induced Liver Injury , Creatinine/blood , Drug Combinations , Female , Glutathione/metabolism , L-Lactate Dehydrogenase/metabolism , Liver/drug effects , Liver/metabolism , Liver/pathology , Liver Diseases/metabolism , Liver Diseases/pathology , Magnoliopsida/chemistry , Magnoliopsida/toxicity , Male , Mice , Organ Size/drug effects , Plant Extracts/toxicity , Plants, Medicinal/toxicity , Protective Agents/toxicity , gamma-Glutamyltransferase/metabolismABSTRACT
In the biphasic model of triton-induced hyperlipidemia, C. sativum at a dose of 1g/kg body weight reduced cholesterol and triglycerides levels in both synthesis and excretory phases in rats, and the results were comparable with that of Liponil, a commercially available herbal hypolipidemic drug. The results suggest that coriander decreases the uptake and enhances the breakdown of lipids. From the study it can be assumed that coriander has the potential to be popularized as a household herbal remedy with preventive and curative effect against hyperlipidemia.
Subject(s)
Cholesterol/metabolism , Coriandrum/chemistry , Hyperlipidemias/drug therapy , Hypolipidemic Agents/therapeutic use , Plants, Medicinal , Triglycerides/metabolism , Animals , Hyperlipidemias/blood , Hyperlipidemias/chemically induced , Male , Plant Extracts/pharmacology , Polyethylene Glycols , Rats , Rats, WistarABSTRACT
Alloxan-induced diabetic rats were treated with multiple herbal preparation besides a control group receiving distilled water. The levels of glucose and alkaline phosphatase (ALP) increased abnormally in the alloxan treated group and the same were normalized upon treatment with the herbal preparation. The levels of blood urea nitrogen (BUN), alanine aminotransferase (ALT), protein and albumin in all groups remained unaltered. However, weekly body weight gain which got significantly altered in the alloxan-treated group was normalized by treatment with the herbal preparation. On the whole, a profound hypoglycemic effect was observed by the multiple herbal treatment in the diabetic rats.