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Zhongguo Zhong Yao Za Zhi ; 49(4): 884-893, 2024 Feb.
Article in Chinese | MEDLINE | ID: mdl-38621895

ABSTRACT

Sepsis is a systemic inflammatory response syndrome caused by infection, with high morbidity and mortality. Sepsis-induced liver injury(SILI) is one of the manifestations of sepsis-induced multiple organ syndrome. At present, there is no recommended pharmacological intervention for the treatment of SILI. traditional Chinese medicine(TCM), based on the holism and dialectical treatment concept, shows the therapeutic characteristics of multi-target and multi-pathway and can comprehensively prevent and treat SILI by interfering with inflammatory factors, inflammatory signaling pathways, and anti-oxidative stress and inhibiting apoptosis. This article reviewed the experimental studies on the treatment of SILI with TCM to clarify its pathogenic mechanism and therapeutic characteristics, so as to provide more ideas and directions for the development or preparation of new drugs.


Subject(s)
Chemical and Drug Induced Liver Injury, Chronic , Drugs, Chinese Herbal , Sepsis , Humans , Medicine, Chinese Traditional , Chemical and Drug Induced Liver Injury, Chronic/drug therapy , Sepsis/complications , Sepsis/drug therapy , Apoptosis , Signal Transduction , Drugs, Chinese Herbal/therapeutic use , Drugs, Chinese Herbal/pharmacology
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