ABSTRACT
Allicin is a sulfur-containing compound extracted from raw garlic (Allium sativum L.). We compared the effect of allicin addition on growth performance, serum biochemical parameters, and rumen microbiota of goats compared to monensin. Twenty-four Anhui white goats were assigned randomly to one of three dietary treatments: 1) a basal diet (CON); 2) the basal diet with allicin addition at 750 mg per head per day (AC); 3) the basal diet with monensin addition at 30 mg per kg of diet (MS). Animals were fed for 8 weeks. Results showed the average daily gain, and feed efficiency was increased with allicin and monensin addition. Serum levels of IgG, total superoxide dismutase, and glutathione peroxidase were higher in the AC group than those in the CON and MS groups. The microbiota analysis revealed that monensin addition mainly affected genera related to carbohydrate and protein metabolism, and allicin mainly affected genera related to energy metabolism and intestinal health. In conclusion, allicin could improve growth performance and have advantages over monensin in improving the antioxidant capacity and immune function of goats. Allicin may be a potential alternative to monensin.
Subject(s)
Disulfides , Garlic , Microbiota , Sulfinic Acids , Animals , Animal Feed/analysis , Antioxidants/metabolism , Diet/veterinary , Dietary Supplements/analysis , Goats/metabolism , Monensin/pharmacology , Rumen/metabolismABSTRACT
AIM: To investigate antimalarial mechanism of Qinghaosu ( QHS) and its derivatives. METHODS: The electronic structure of QHS and its derivatives were completely optimized and calculated at B3LYP/6-31G * level, while the route was at HF/STO-3G level. RESULTS: The peroxide bridge is the active center of QHS and induced by ferrous iron to produce cyclic product. CONCLUSION: Heme can link with QHS derivatives.