ABSTRACT
Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based on the types of injured target cells. The CSH guidelines summarized the epidemiology, pathogenesis, pathology, and clinical manifestation and gives 16 evidence-based recommendations on diagnosis, differential diagnosis, treatment, and prevention of DILI.
Subject(s)
Chemical and Drug Induced Liver Injury/epidemiology , Cholestasis/chemically induced , Dietary Supplements/adverse effects , Liver Diseases/epidemiology , Anti-Bacterial Agents/adverse effects , Anti-Bacterial Agents/toxicity , Anti-Infective Agents/adverse effects , Anti-Infective Agents/toxicity , Chemical and Drug Induced Liver Injury/pathology , Chemical and Drug Induced Liver Injury/physiopathology , Chemical and Drug Induced Liver Injury/prevention & control , China/epidemiology , Cholestasis/complications , Cholestasis/pathology , Diagnosis, Differential , Dietary Supplements/toxicity , Drugs, Chinese Herbal/adverse effects , Female , Guidelines as Topic , Humans , Incidence , Liver Diseases/pathology , Liver Diseases/physiopathology , Liver Diseases/therapy , Male , Prognosis , Risk Factors , Severity of Illness IndexABSTRACT
The method for the determination of the trace elements in Shengmai San by inductively coupled plasma atomic emission spectrometry (ICP-AES) was presented. The contents and solubility of the trace elements in Shengmai San with different ginseng were compared. The recovery rates of the procedure were between 95.2% and 112.4%, and the RSDs were between 0.70% and 5.9%. When the ginseng was western genseng in the Shengmai San, the solubility of trace elements was the highest. The couple of Shengmai San was proved reasonable. The method was simple, rapid, precise, convenient and suitable for traditional Chinese medicine.
Subject(s)
Boron/analysis , Drugs, Chinese Herbal/chemistry , Metals/analysis , Selenium/analysis , Spectrophotometry, Atomic/methods , Drug Combinations , Panax/chemistryABSTRACT
The method for the determination of trace elements in danggui blood-supplementing decoction by inductively coupled plasma atomic emission spectrometry(ICP-AES) was presented. The contents and solubility of the trace elements in Angelica sinensis and Radix Astragali of different proportion were compared. The recovery rates of the procedure were between 97. 2% and 115. 6%. The RSDs were between 0. 82% and 5. 56%. When Angelica sinensis: Radix Astragali was 1 : 5, the solubility of trace elements was the highest. The couplng of danggui blood-supplementing decoction was proved reasonable. The method was simple, rapid, precise, convenient and suitable for traditional Chinese medicine.