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Therapeutic Methods and Therapies TCIM
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1.
Environ Toxicol Pharmacol ; 46: 270-276, 2016 Sep.
Article in English | MEDLINE | ID: mdl-27522546

ABSTRACT

Although numerous hypotheses have been proposed to prevent chemotherapy-induced alopecia (CIA), effective pharmaceuticals have yet to be developed. In our study, the back hairs of C57BL/6 mice were factitiously removed. These mice were then treated with cedrol or minoxidil daily. Mice with early-stage anagen VI hair follicles were treated with cyclophosphamide (CYP, 125mg/kg) to induce alopecia. The CYP-damaged hair follicles were observed and quantified by using a digital photomicrograph. The results demonstrated that the minoxidil-treated mice suffered from complete alopecia similar to the model 6days after CYP administration. Simultaneously, the cedrol-treated (200mg/kg) mice manifested mild alopecia with 40% suppression. Histological observation revealed that anagen hair follicles of the cedrol-pretreated mice (82.5%) likely provided from damage compared with the sparse and dystrophic hair follicles of the model mice (37.0%). Therefore, the use of topical cedrol can prevent hair follicle dystrophy and provide local protection against CIA.


Subject(s)
Alopecia/prevention & control , Antineoplastic Agents, Alkylating/toxicity , Cyclophosphamide/toxicity , Terpenes/therapeutic use , Alopecia/chemically induced , Animals , Cupressaceae/chemistry , Dermatitis, Contact/etiology , Dermatitis, Contact/immunology , Disease Models, Animal , Female , Hair Follicle/drug effects , Hair Follicle/growth & development , Hair Follicle/pathology , Mice, Inbred C57BL , Plant Leaves/chemistry , Polycyclic Sesquiterpenes , Skin/drug effects , Skin/immunology , Terpenes/administration & dosage , Terpenes/isolation & purification , Terpenes/toxicity , Toxicity Tests, Acute
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