ABSTRACT
The time course of changes in lipid peroxidation and the characteristics of endogenous intoxication were studied in the treatment of patients with gonarthrosis. The findings suggest the positive changes in the biochemical parameters that characterize endogenous intoxication and recovery of the body's antioxidant status despite the activation of prooxidative processes.
Subject(s)
Anticoagulants/therapeutic use , Arthritis/therapy , Hirudin Therapy , Animals , Arthritis/blood , Arthritis/metabolism , Arthritis/physiopathology , Female , Humans , Leeches , Lipid Peroxidation/drug effects , Malondialdehyde/blood , Middle Aged , Oxidative Stress/drug effects , Superoxide Dismutase/bloodABSTRACT
The results of conservative treatment with the use of hirudotherapy of patients presenting with bilateral gonarthrosis were evaluated by biochemical analysis of their serum and urine samples. The study revealed changes of mineral, carbohydrate, and lipid metabolism suggestive of the positive homeostatic effect of hirudotherapy at the local and systemic levels. This finding gives reason to recommend hirudotherapy for the treatment and prevention of osteoarthrosis.