ABSTRACT
In this work, we present the in vitro schistosomicidal activity evaluation of the most active dichloromethane fraction (FDm) (ED50=83.5µg/mL) and of a mixture of the major alkaloids ((-)-cassine/(-)-spectaline, C/E) (ED50=37.4µg/mL) from the flowers of Senna spectabilis against adult worms and cercariae. We also demonstrate other toxic effects including paralysis of the adult worms, inhibition of the secretory activity, tegument lesions and cercaricidal activity. In the association test of Praziquantel (PZQ)-C/E, we observed up to 80% mortality of Schistosoma mansoni in comparison to PZQ monotherapy. Due to the diversity of the toxic effects, the schistosomicidal activity of C/E is likely a result of a multitarget mechanism involving the tegument, secretory system and neuromotor action.
Subject(s)
Alkaloids/chemistry , Fabaceae/chemistry , Piperidines/chemistry , Plant Extracts/chemistry , Schistosomicides/chemistry , Alkaloids/isolation & purification , Alkaloids/pharmacology , Animals , Fabaceae/metabolism , Female , Flowers/chemistry , Flowers/metabolism , Ketones/isolation & purification , Ketones/pharmacology , Male , Motor Activity/drug effects , Piperidines/isolation & purification , Piperidines/pharmacology , Schistosoma mansoni/drug effects , Schistosomicides/isolation & purification , Schistosomicides/pharmacology , StereoisomerismABSTRACT
Este trabalho, que constitue a indicacao dos medicamentos, drogas e apparelhos indispensaveis a montagem de uma pharmacia homoeopathica, foi executado como colaboracao em um relatorio sobre regulamentacao de pharmacias apresentado a ex-Directoria Geral de Saude Publica, em 1916, pela Associacao Brasileira de Pharmaceuticos