ABSTRACT
On the basis of earlier executed studies of hypotensive effect of dinitrosyl iron complexes (DNIC) with glutathione, the drug has been created in industrial conditions named oxacom. Preliminary pharmacological studies of oxacom have not revealed negative qualities. The drug has been now tested in 14 healthy men in whom at single intravenous introduction it caused typical response - a decrease of diastolic as well as systolic arterial pressure on 24-27 mmHg through 3-4 min with subsequent very slow restoration in 8-10 hours. The heart rate after initial rise was quickly normalized. Echocardiography revealed unaltered cardiac output in spite of reduced cardiac filling by 28%. The multilateral analysis of clinical and biochemical data has revealed an absence of essential alterations which could lead to pathological consequences. The drug is recommended for carrying out of the second phase of clinical trial. The comparative study of the efficiency of hypotensive action of oxacom, S-nitrosoglutathione (GS-NO) and sodium nitrite (NO2) in rats has shown that the duration of effect was the greatest at oxacom action.
Subject(s)
Blood Pressure/drug effects , Glutathione , Hypertension/drug therapy , Iron , Nitrogen Oxides , S-Nitrosoglutathione/pharmacokinetics , Sodium Nitrite/pharmacokinetics , Adult , Animals , Biological Availability , Drug Evaluation, Preclinical/methods , Drug Monitoring/methods , Glutathione/administration & dosage , Glutathione/adverse effects , Glutathione/pharmacokinetics , Glutathione/pharmacology , Humans , Hypertension/metabolism , Hypertension/physiopathology , Hypotension/chemically induced , Infusions, Intravenous , Iron/administration & dosage , Iron/adverse effects , Iron/pharmacokinetics , Iron/pharmacology , Male , Nitric Oxide/metabolism , Nitrogen Oxides/administration & dosage , Nitrogen Oxides/adverse effects , Nitrogen Oxides/pharmacokinetics , Nitrogen Oxides/pharmacology , Rats , Rats, Wistar , Therapeutic Equivalency , Therapies, Investigational , Treatment OutcomeABSTRACT
PGE levels were measured in duodenal ulcer patients treated by H2-blockers of histamine receptors of hyperbaric oxygenation (HBO). Histadyl is shown to cause a marked decrease in gastric juice PGE concentrations in contrast to HBO that raised PGE levels close to normal values. It is thought necessary to administer long-term maintenance therapy after cicatrisation of the ulcer lesion with the drugs improving local microcirculation and stimulating bicarbonates production in gastric mucosa, synthetic prostaglandins analogues, in particular.