ABSTRACT
Two new C31 triterpenes, polysimiaric acid A (1) and B (2) as well as one new clerodane diterpenoid, 16,16-dimethoxy-cleroda-3,13Z-dien-15-oic acid (3), together with six known compounds were isolated from Polyalthia simiarum. Their structures were determined by analysis of 1D and 2D NMR data. Three new compounds were tested for their cytotoxicity against five human tumour cell lines. Compound 3 showed cytotoxic activities against SMMC-7721 with the IC50 value of 22.43 µM.
Subject(s)
Antineoplastic Agents, Phytogenic/pharmacology , Diterpenes, Clerodane/pharmacology , Polyalthia/chemistry , Terpenes/pharmacology , Antineoplastic Agents, Phytogenic/isolation & purification , Cell Line, Tumor , China , Diterpenes, Clerodane/isolation & purification , Humans , Molecular Structure , Plant Leaves/chemistry , Terpenes/isolation & purificationABSTRACT
Fractionation of the EtOH extract from the fruits of Broussonetia papyrifera led to the isolation of 15 phenolic compounds (1-15). Their structures were identified using spectroscopic methods. Among these compounds, 1 and 2 are new and 3-15 were isolated from this plant for the first time. Antioxidant activities of compounds 2-15 against H(2)O(2)-induced injury in SY5Y cells and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities were evaluated.
Subject(s)
Antioxidants/isolation & purification , Antioxidants/pharmacology , Biphenyl Compounds/pharmacology , Broussonetia/chemistry , Drugs, Chinese Herbal/isolation & purification , Drugs, Chinese Herbal/pharmacology , Free Radical Scavengers/isolation & purification , Free Radical Scavengers/pharmacology , Phenols/isolation & purification , Phenols/pharmacology , Picrates/pharmacology , Antioxidants/chemistry , Drugs, Chinese Herbal/chemistry , Free Radical Scavengers/chemistry , Fruit/chemistry , Humans , Phenols/chemistryABSTRACT
Nine new lignans, chushizisins A-I (1-9), and three known lignans, threo-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol (10), erythro-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol (11), and 3-[2-(4- hydroxyphenyl)-3-hydroxymethyl-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol (12), were isolated from the fruits of Broussonetia papyrifera. Their structures were elucidated using spectroscopic methods. Compounds 1, 5, 6, 8, 9, and 11 exhibited antioxidant activities against H(2)O(2)-induced impairment in PC12 cells, while compounds 1, 2, 4, 7, and 11 showed DPPH radical-scavenging activities with IC(50) values of 236.8, 156.3, 273.9, 281.1, and 60.9 microM, respectively.