1.
Lancet
; 2(8663): 591-3, 1989 Sep 09.
Article
in English
| MEDLINE
| ID: mdl-2570286
ABSTRACT
UK 69 578 is a competitive inhibitor of endopeptidase 24.11 (the enzyme that degrades atrial natriuretic factor) in vitro. In vivo, UK 69 578 has renal and cardiovascular effects similar to low-dose atrial natriuretic factor infusion, and may be a useful agent in hypertension and heart failure.