One year oral Toxicity of D-004, a lipid extract from Roystonea regia fruits, in Sprague Dawley rats.

D-004, a lipid extract of royal palm (Roystonea regia) fruits that contains a reproducible mixture of fatty acids, has been shown to prevent testosterone and phenylephrine-induced prostate hyperplasia in rodents. This study investigated the long-term oral toxicity of D-004 in rats. Rats from both sexes were randomized into four groups (20 rats sex/group): a control and three treated with D-004 (800, 1500 or 2000 mg/kg/day, respectively). At study completion, rats were sacrificed under anaesthesia. Determinations of blood biochemical and haematological parameters and organ weight were done. Also, necropsy and histopathological studies were performed. Four of 160 rats died before study completion. No clinical signs of toxicity were observed throughout the study. Food and water consumption, bodyweight, blood biochemical and haematological parameters, organ weight ratios and histopathological findings were similar in control and treated groups. The histological lesions found in treated animals are commonly present in this specie and strain according to literature and our historical data. In conclusion, long-term (12 months) oral treatment of rats with D-004 (800-2000 mg/kg/day) did not show evidences of D-004-related toxicity under our conditions. The highest dose tested (2000 mg/kg) was a no-observed adverse effect level in this study.

Anestesia intracervical en la histeroscopia / Intracervical anesthesia in hysteroscopy

Objetivo: Valorar los resultados obtenidos con la utilización de anestesia intracervical con jeringa y aguja de dentista en la histeroscopia. Material y métodos: Desde el 1 de enero hasta el 30 de junio se han realizado 622 histeroscopias en nuestra consulta. A las mujeres a quienes no se puede practicar la histeroscopia porque sienten dolor, se les inyecta anestesia intracervical con jeringa y aguja de dentista. Resultados: De las 622 histeroscopias realizadas en el primer semestre de 2004, han precisado anestesia local 90 mujeres (14,5%). El porcentaje de histeroscopias que no se han podido realizar en consulta ha sido del 1,7%, bastante menor que el observado en años anteriores: en el primer semestre de 2000 fue del 4,9%, en 2001 y 2002 del 8,3%, y en 2003 del 6,1%. Conclusiones: Al revisar la bibliografía, todos los estudios han encontrado beneficioso el uso de anestesia intracervical en la histeroscopia, y hacen hincapié en la importancia de la selección de las pacientes. Nuestro estudio llega a las mismas conclusiones, y aporta la ventaja que supone la utilización de la jeringa y aguja de dentista, con lo cual se consigue una correcta analgesia y una mejor tolerancia de la mujer, sin olvidarnos del ahorro económico que supone la anestesia local respecto a la general

Objective: To evaluate the results obtained with the use of intracervical anesthesia injected with a dental syringe in outpatient hysteroscopy. Material and methods: From January 1st to June 30th 2004, we performed 622 outpatient hysteroscopies. Intracervical anesthesia was injected with a dental syringe in women who did not tolerate the pain during hysteroscopy. Results: Of 622 outpatient hysteroscopies performed in the first semester of 2004, 90 women required local anesthesia (14.5%). The percentage of hysteroscopies that could not be performed in the office was 1.7%, less than that observed in previous years (4.9% in the first semester of 2000, 8.3% in 2001 and 2002 and 6.1% in 2003). Conclusions: A review of the literature reveals that all studies have found intracervical anesthesia to be beneficial in outpatient hysteroscopy, emphasizing the importance of patient selection. Our study supports these conclusions and additionally reports the advantage of the use of a dental syringe, which allows adequate analgesia and better patient tolerance, as well as economic savings in comparison with general anesthesia