Subject(s)
Adjuvants, Immunologic/administration & dosage , Amino Acids/administration & dosage , Tuberculosis/immunology , Tuberculosis/therapy , Adjuvants, Immunologic/pharmacology , Amino Acids/metabolism , Amino Acids/pharmacology , Amino Acids/therapeutic use , Animals , Guinea Pigs , Humans , Hydrocarbons, Aromatic/pharmacology , Liver/drug effects , Mycobacterium tuberculosis/drug effects , Rats , Xenobiotics/adverse effectsABSTRACT
Harmful environmental agents [polycyclic aromatic hydrocarbons (PAH)] have been ascertained to greatly stimulate the biosynthesis of arginine and urea and reduce the amount of sulfur-containing metabolites in the liver of experimental animals by increasing the level of sulfur sulfate. Against this background, contamination with Mycobacteria tuberculosis (MBT) inhibits the activity of arginine and drastically decreases its amount by elevating the concentration of sulfur-containing metabolites. The supplementary administration of sodium glutamate to animals receiving PAH and MBT potentiates a decrease in nitrogen-rich metabolites and increases the level of sulfur-containing metabolites guinea pigs, tuberculosis resistance being on the rise. Under the influence of a combined action of PAH and MBT, the mutagenic effect of the former lowered in rats.
Subject(s)
Mycobacterium tuberculosis , Polycyclic Aromatic Hydrocarbons/adverse effects , Tuberculosis, Pulmonary , Animals , Antitubercular Agents/administration & dosage , Arginase/analysis , Drug Combinations , Guinea Pigs , Isoniazid/administration & dosage , Liver/drug effects , Liver/pathology , Lung/drug effects , Lung/pathology , Rats , Taurine/administration & dosage , Tuberculosis, Pulmonary/drug therapy , Tuberculosis, Pulmonary/immunology , Tuberculosis, Pulmonary/pathologyABSTRACT
The authors evaluated the capacities of transcranial electrostimulation and the specific features of its impact on reparative regeneration of damaged tissues of different types, such as the dermal and gastroduodenal epithelium, hepatic cells, connective tissue, peripheral nerve fibers, on animal experimental pathological models and compared with the results of treatment of respective pathology in patients.
Subject(s)
Brain/physiology , Burns/therapy , Electric Stimulation Therapy , Endorphins/physiology , Hearing Loss, Sensorineural/therapy , Myocardial Infarction/therapy , Peptic Ulcer/therapy , Regeneration/physiology , Adult , Animals , Burns/blood , Child , Electric Stimulation Therapy/instrumentation , Electric Stimulation Therapy/methods , Electrodes , Endorphins/blood , Hearing Loss, Sensorineural/blood , Humans , Liver Regeneration/physiology , Myocardial Infarction/blood , Nerve Regeneration/physiology , Peptic Ulcer/blood , Rats , Time Factors , Wound Healing/physiologyABSTRACT
Sixty three patients with primary excessive myocardial infarction (MI) were examined. Transcranial electric stimulation (TES) was demonstrated to contribute to more rapid formation of a postinfarction scar, development of compensatory hypertrophy of the preserved myocardium, and improvement of cardiac contractility. TES-induced activation of the endogenous opioid system was found to be one of the mechanisms responsible for stimulation of reparative processes in patients with MI. Introduction of TES into the multimodality therapy for MI improves the clinical picture of the disease, promoting diminution of circulatory failure signs and relapses of angina-associated pains and favoring decrease in the long-term course of MI and frequency of cardiac arrhythmias.