ABSTRACT
The influence of vitamin D and ultraviolet irradiation (UVI), used for prevention of vitamin D deficiency, on the state of phosphoric-calcium metabolism was studied in experiments on rats. It has been shown that daily injections of 1-5 IU of vitamin D, and UVI in biodoses from 1/8 to 1/4 promote the maintainance of the normal level of phosphoric-calcium metabolism. When UVI was applied according to the widely used "basic scheme" (in biodoses from 1/4 to 2 1/2) the following anomalies were recorded: a three-fold increase of 25-ON-D3 concentration in the blood plasma, hyperphosphatemia, a tendency to hypercalcemia. The use of higher doses of UVI led to a further increase of 25-OH-D3 level, hypophosphatemia, hypercalcemia, kidney and heart calcification. The data obtained have evidenced a possibility of vitamin D intoxication during UVI.
Subject(s)
Calcium/radiation effects , Phosphorus/radiation effects , Ultraviolet Rays , Animals , Calcium/blood , Cholecalciferol/administration & dosage , Cholecalciferol/blood , Cholecalciferol/poisoning , Dose-Response Relationship, Drug , Dose-Response Relationship, Radiation , Male , Phosphorus/blood , Rats , Rats, Inbred Strains , Vitamin D Deficiency/blood , Vitamin D Deficiency/prevention & controlABSTRACT
Analysis of HBO use in 287 CHD patients has shown that individual HBO regimens can be selected both by an increase in tissue pO2 in response to a HBO session and by an initial type of patients' blood circulation.
Subject(s)
Coronary Disease/therapy , Hyperbaric Oxygenation/methods , Aged , Angina Pectoris/metabolism , Angina Pectoris/therapy , Combined Modality Therapy , Coronary Disease/metabolism , Forearm , Humans , Middle Aged , Oxygen Consumption , Partial Pressure , Skin/metabolismABSTRACT
An analysis of treatment of 122 patients has shown that the effectiveness of HBO can be enhanced by a combination with continuous intraarterial infusions and lumbar sympathectomy. An important condition for reaching the maximum effect of HBO is an increase of the initially low cardiac output in such patients.
Subject(s)
Arterial Occlusive Diseases/therapy , Hyperbaric Oxygenation , Leg/blood supply , Combined Modality Therapy , Dextrans/administration & dosage , Follow-Up Studies , Humans , Infusions, Intra-Arterial , Lumbosacral Region/innervation , Niacin/administration & dosage , Pentoxifylline/administration & dosage , Sodium Chloride/administration & dosage , SympathectomyABSTRACT
Tests conducted on albino rats of the Wistar line demonstrated that introduction of large doses of ergocalciferol (vitamin D2) to animals kept on a strontium-rich diet exhibiting signs of rickets brings about the development in them of specific manifestations of the D-vitamin activity, viz. rising level of calcium, strontium and inorganic phosphorus in the blood serum, lowering of the alkaline phosphatase activity and a greater degree of the soft tissues calcification.