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Therapeutic Methods and Therapies TCIM
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1.
Bull Exp Biol Med ; 163(4): 550-553, 2017 Aug.
Article in English | MEDLINE | ID: mdl-28853087

ABSTRACT

In primary culture of mouse hippocampal neurons, peptide EDR (200 ng/ml) under conditions of amyloid synaptotoxicity (a model of Alzheimer's disease) increased the number of mushroom spines by 71% and returned this parameter to the normal level. Under the same conditions, tripeptide KED (200 ng/ml) increased the number of mushroom spines in hippocampal neurons by 20%. Tripeptide EDR can be recommended for further experimental study as a candidate neuroprotective agent for prevention and treatment of Alzheimer's disease.


Subject(s)
Alzheimer Disease/metabolism , Amyloid beta-Peptides/metabolism , Dendritic Spines/metabolism , Hippocampus/cytology , Neurons/drug effects , Peptides/therapeutic use , Animals , Cells, Cultured , Disease Models, Animal , Mice
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