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Bioorg Med Chem Lett
; 16(17): 4592-5, 2006 Sep 01.
Article
in English
| MEDLINE
| ID: mdl-16793261
ABSTRACT
A simple and efficient method for the synthesis of N3-substituted 3,4-dihydropyrimidinones by aza-Michael addition reactions of 3,4-dihydropyrimidinones to alpha,beta-ethylenic compounds catalyzed by KF/Al(2)O(3) is described. The advantage of this method is high regioselectivity, high purity, and the use of a cheaper, milder, and efficient catalyst for the hetero-Michael addition reaction.