ABSTRACT
The purpose of this study is to regulate the ROS (Reactive oxygen species) defense system in cardiac damage induced by CCl4(Carbon tetra chloride) in rats using Hybanthus enneaspermus. Administration of CCl4induces damage in the heart of rats as proved by estimation of antioxidant enzymes such as, SOD (Superoxide dismutase), CAT (catalase), GPx (Glutathione Peroxdiase), GR (Glutathione Reductase), GST (Glutathione-S-Transferaes). However, treatment with HEE in CCl4intoxicated rats was found to be protected the heart, as indicated by the enzyme level in serum. A significant increment of serum enzymes level such as SOD, CAT, GPx, GR and GST were observed following HEE treatment during CCl4intoxication whereas MDA (Malondialdehyde) level in HEE treated rats were decreased. The results of our experiment suggest that the treatment of HEE may be the critical remedy for the adverse effect of CCl4in heart function.