ABSTRACT
There are numerous medicinal benefits from herbal plants, with many herbal medicines being used as 'Jamu', 'standardized herbal medicines' and phytopharmaceuticals. Physalis angulata Linn. (P. angulata L.), a plant utilized for both medicinal and food consumption purposes in a number of tropical and subtropical nations, is widely studied for its beneficial properties. The present review summarized the scientific evidence which suggested that P. angulata L. possesses antibacterial, anticancer, antiparasitic, anti-inflammatory, antifibrotic and antidiabetic properties. Furthermore, the various pharmacological studies that have been conducted utilizing in vivo and in vitro models, as well as the identification of phytochemical components with therapeutic value are described. In addition, the present review explained the solvents and the toxicity tests that were used for the investigation of P. angulata L. The authors aspire that this literature review will provide an overview for researchers regarding the scientific progress of P. angulata L. over the past ten years and the potential areas of future research.
ABSTRACT
BACKGROUND AND OBJECTIVE: Diabetes mellitus is the third leading cause of death in Indonesia (6.7 %), followed by stroke (21.1 %) and coronary heart disease (12.9 %). The prevalence of diabetes worldwide continues to increase on a yearly basis, including in Indonesia. Diabetes is a significant burden for many countries due to the high costs of treatment and reduced productivity of diabetes patients. Comprehensive strategies to prevent and treat diabetes are therefore mandatory. Oral hypoglycemic drugs are the first-line therapy for diabetes mellitus patients; however, these oral drugs still have several side effects. Therefore, it is necessary to conduct studies on medicinal plants with hypoglycemic effects to identify substances that have an anti-diabetic potential resembling physiological processes in the body. Indonesian people often use herbal medicines empirically, but the benefits have not been scientifically documented. Melinjo (Gnetum gnemon L.) is a native Indonesian gymnosperm plant, and the seeds are often processed into food. Melinjo seeds extract contains many polyphenols, including trans-resveratrol. CONCLUSION: Studies on the health benefits of resveratrol are widely available, including antidiabetes and blood sugar control in patients with type 2 diabetes.