ABSTRACT
BACKGROUND AND STUDY AIMS: The approach to small bowel preparation before capsule endoscopy (CE) is still suboptimal. PATIENTS AND METHODS: One hundred eighty patients were randomly allocated to 3 groups. Patients in Group A took 250âmL 20% mannitol and 1âL 0.9% saline orally at 05:00âhours on the day of the procedure. In Group B the same preparation was taken at 20:00 on the day before, and at 05:00 on the day of CE; in addition, 20âmL oral simethicone was taken 30âminutes before CE. Group C was treated identically to Group B, except that the patients fasted for 3 days and took 3âg senna orally 3 times daily before CE. The length of bowel containing green luminal contents was assessed by ImageJ software and bowel cleanliness was evaluated by computed assessment of the cleansing score. RESULTS: Cleansing of the whole small bowel and the distal small bowel were significantly different between the 3 groups (χâ=â22.470, Pâ=â.000; χâ=â17.029, Pâ=â.000, respectively). There were also significant differences between the 3 groups in the length of small bowel and specifically the length of the distal small bowel containing green luminal contents (χâ=â12.390, Pâ=â.000, χâ=â15.141, Pâ=â.000, respectively), but not with regard to the proximal small bowel (χâ=â0.678, Pâ=â.509). CONCLUSIONS: Three days fasting and oral senna, combined with 20% mannitol and simethicone, before CE, can reduce the effects of bile on the small bowel and improve small bowel cleansing, especially in the distal small intestine.