ABSTRACT
Using a TV unit for microcirculation studies, we studied the density of the entire microvascular network and its arterial compartment in the pia mater of the sensorimotor cortex in intact young and aged rats (2-3 and 22-24 months) and aged rats after a course of vascular peptide bioregulator Slavinorm. The experiments showed that the density of microvascular network in intact animals decreased by 1.6 times with aging. Treatment with the peptide bioregulator 2.5-fold increased the density of the microvascular network in aged rats in comparison with intact animals of the same age, the density of the arterial compartment of the microvascular network in the pia mater increased by 2.8 times.
Subject(s)
Angiogenesis Inducing Agents/pharmacology , Microvessels/drug effects , Pia Mater/blood supply , Proteins/pharmacology , Sensorimotor Cortex/blood supply , Aging , Animals , Drug Evaluation, Preclinical , Male , Neovascularization, Physiologic/drug effects , Rats, Inbred WKYABSTRACT
The research of biological activity of peptide geroprotector Slavinorm on the basis of calf aorta extract was conducted in experimental models of hypertension and chloride-calcium arrhythmia. The research results showed that in experimental model of arrhythmia in rats induced by pituitrin administration, intraventricular and intramuscular introduction of Slavinorm in therapeutical dose had caused to leveling of hypertension symptoms. That was expressed in normalization of blood pressure characteristics, body weight, heart and kidney weight. In the experimental model of chloride-calcium arrhythmia in rats inrtaventricular and intramuscular introduction of Slavinorm showed the ability to predict the arrhythmia development caused by the Calcium Chloride administration. The research results testify to availability of the medication research in the capacity of the medication for treatment of age related pathology conditioned by vessels impaired function.
Subject(s)
Aorta/chemistry , Arrhythmias, Cardiac , Blood Pressure/drug effects , Hypertension , Peptides , Animals , Anti-Arrhythmia Agents/pharmacology , Antihypertensive Agents/pharmacology , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/drug therapy , Calcium Chloride , Cattle , Dietary Supplements , Disease Models, Animal , Drug Administration Routes , Drug Administration Schedule , Drug Discovery , Hypertension/chemically induced , Hypertension/drug therapy , Peptides/chemistry , Peptides/pharmacology , Pituitary Hormones, Posterior , Protective Agents/pharmacology , Rats , Treatment OutcomeABSTRACT
A comprehensive treatment with Likopid of chronic generalized parodontitis in 114 elderly and senile patients was carried out. The state of mechanisms of innate immunity (phagocytosis mechanisms) as well as the profile of proinflammatory cytokines was assessed. The effect of antibiotic-resistant strains of prior microflora on the combined therapy of patients of different age with chronic generalized parodontitis was studied. It is established that due to presence of various types of opportunistic pathogens in patients of different age with parodontitis using the prophylactic antibiotics for the empirical (to determine the antibiotic resistance), a combination of Metronidazole and Lincomycin with the mandatory appointment of immunomodulatory drugs for activation of monocyte-phagocytic system of the patient elderly is most advisable. Use of the drug , "Likopid" significantly improves the results of treatment the elderly and old patients with chronic generalized parodonthitis.
Subject(s)
Acetylmuramyl-Alanyl-Isoglutamine/analogs & derivatives , Anti-Bacterial Agents/therapeutic use , Antibiotic Prophylaxis/methods , Chronic Periodontitis/drug therapy , Combined Modality Therapy/methods , Periodontium/drug effects , Phagocytosis/drug effects , Acetylmuramyl-Alanyl-Isoglutamine/therapeutic use , Adult , Aged , Chronic Periodontitis/immunology , Chronic Periodontitis/physiopathology , Cytokines/immunology , Drug Resistance, Microbial , Female , Humans , Immunologic Factors/therapeutic use , Lincomycin/therapeutic use , Male , Metronidazole/therapeutic use , Microbial Sensitivity Tests , Middle Aged , Monitoring, Immunologic , Periodontium/immunology , Periodontium/microbiology , Severity of Illness Index , Treatment OutcomeABSTRACT
In the above study, the comparison of efficiency of complex treatment of elderly and senile patients with fractures of mandibula has been carried out. After osteosynthesis of mandibula with mini-plates, frequency of development of traumatic osteomyelitis in these patients was lower than that after osteosynthesis by means of bone suture, especially in the group of patients who were admitted with signs of inflammation of osteal wound, where traumatic osteomyelitis developed 3 times less often than after osteosynthesis with bone suture. At bilateral fractures of mandibula, osteosynthesis with bone suture is not prescribed to the elderly patients who are admitted with signs of inflammation of osteal wound. Application of mini-plates for osteosynthesis at fractures of mandibula in the elderly patients enabled to restore mandibula motion and chewing function within much earlier terms.
Subject(s)
Fracture Fixation, Internal/methods , Health Services for the Aged/organization & administration , Mandibular Fractures/surgery , Aged , Aged, 80 and over , Bone Plates , Female , Fracture Fixation, Internal/instrumentation , Fracture Healing/radiation effects , Humans , Low-Level Light Therapy , Male , Mandibular Fractures/diagnostic imaging , Mandibular Fractures/radiotherapy , Middle Aged , Radiography , Treatment OutcomeABSTRACT
The study of the geriatric properties of the bioantioxidant complex "Neovitin" received from a biomass of ginseng, against formation of radio gene tumors was continued. The preparation was applied to the laboratory animals exposed to chronic gamma irradiation by low doses, by all period of irradiation and thirty days in the post beam period. The expressed anticancerogenic effect of "Neovitin", reducing formation of radio gene tumors, including malignant, as well as reduction of a spectrum of new growths were proved.
Subject(s)
Aging, Premature/prevention & control , Antioxidants/therapeutic use , Neoplasms, Radiation-Induced/prevention & control , Panax/chemistry , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents/therapeutic use , Aging, Premature/etiology , Aging, Premature/pathology , Animals , Antioxidants/administration & dosage , Antioxidants/isolation & purification , Dietary Supplements , Gamma Rays/adverse effects , Neoplasms, Radiation-Induced/etiology , Neoplasms, Radiation-Induced/pathology , Plant Extracts/administration & dosage , Plant Extracts/isolation & purification , Plant Extracts/therapeutic use , Radiation Injuries, Experimental/complications , Radiation Injuries, Experimental/pathology , Radiation-Protective Agents/administration & dosage , Radiation-Protective Agents/isolation & purification , RatsABSTRACT
The specificity of antisera, obtained by the immunization of rabbits with the conjugated antigenic preparations of the thymic factor, have been evaluated by the method of immunochemical analysis. To carry out the comparative study, polypeptides isolated from the pineal body, cortex and white matter of the brain, Thy-1 antigen from the cerebral cortex and insulin have been used. The polypeptides of the thymus and the brain have been found to differ in their amino acid composition and molecular weight. The thymic factor possesses specific antigenic determinants which are absent in the tested preparations of cerebral polypeptides and insulin. The rabbit antisera obtained in this investigation are highly specific and can be used for the immunochemical determination of the thymic factor in the blood and other biological fluids.