ABSTRACT
La anemia por déficit de hierro puede ser habitual en diferentes patologías agudas y crónicas. La vía de primera elección para la reposición de hierro es la oral. Sin embargo, cuando esta vía resulta ineficaz, es mal tolerada o está contraindicada o, cuando hay que tratar una anemia grave o existe la necesidad de recuperación rápida de los niveles de hierro corporal, se recomienda la repleción de hierro por vía endovenosa. El hierro administrado por vía intravenosa permite una rápida y eficiente corrección de los niveles de hierro. Los preparados intravenosos actuales presentan el hierro asociado a moléculas de polisacáridos que facilitan su liberación lenta y controlada, biodisponible para su unión a las proteínas específicas de almacenaje o transportadoras. Gracias a ello, se reduce la toxicidad por hierro libre y se hace posible la administración de altas dosis en intervalos cortos de tiempo. La introducción de preparados que permiten la administración de hierro sin dosis techo, como el hierro isomaltósido, además de reponer eficazmente los niveles de hierro, incide significativamente en la calidad de vida de los pacientes, ya que reduce el número de visitas y desplazamientos a los centros sanitarios, disminuye el número de punciones preservando los accesos venosos, minimiza las interferencias en sus actividades cotidianas y mejora los recursos sanitarios (AU)
Iron deficiency anemia is common in different acute and chronic diseases. The current first line of therapy is oral iron supplementation. However, when this method is ineffective, poorly tolerated, contraindicated, when dealing with severe anemia or facing the need for rapid recovery of iron levels, it is recommended to replete iron intravenously. Administering intravenous iron allows for a fast and efficient correction of iron levels. Current injectable solutions contain iron in combination with polysaccharide molecules which facilitate slow and controlled iron release, making it bioavailable to bind with transport and storage proteins. As a result, toxicity is reduced allowing for high-dose administration in short time intervals. Administering high-dose solutions of intravenous iron, such as iron isomaltoside, apart from effectively replenishing iron levels, significantly improves patients quality of life, reduces the frequency of hospital or clinic visits and decreases punctures preserving the venous access, minimizes interference with daily activities and benefits health care resources (AU)
Subject(s)
Humans , Anemia, Iron-Deficiency/nursing , Anemia, Iron-Deficiency/therapy , Administration, Intravenous/nursing , Anemia/nursing , Anemia/therapy , Intestinal Absorption , Inflammatory Bowel Diseases/nursing , Heart Failure/nursing , Neoplasms/nursingABSTRACT
El dolor ha acompañado al ser humano desde el mismo momento en que éste apareció sobre la tierra. Desde entonces, y a lo largo de toda su historia, el hombre ha tratado no sólo de buscar la razón del mismo, sino también de encontrar remedios para su alivio(AU)
Pain has accompanied human beings since the moment this species appeared on Earth. From that moment on, and throughout his long history, mankind has tried not only to look for the causes of pain but also to find remedies to relieve pain(AU)
Subject(s)
Humans , Male , Female , History, Medieval , History, 15th Century , History, 16th Century , History, 17th Century , History, 18th Century , History, 19th Century , History, 20th Century , Analgesia/history , Pain/history , Mandragora officinarum/therapeutic use , Mandragora , Cannabis , Cocaine/therapeutic use , History of Medicine , Anesthetics, Local/historyABSTRACT
A burn is a tissue lesion which provokes different alterations that vary from topical erythema to total destruction of the structures affected. A burn always produces an alteration in the skin, a lesion in the corneal strata is sufficient to cause the skin to lose its capacity to act as a barrier. The objective the treatment for a burn has is to produce epithelization as soon as possible in order to prevent infection and to reduce functional and esthetic aftereffects. Infection is the main cause of death due to burns due to the growth of endogenous flora or due to external contamination. The use of topical chemotherapy is fundamental to prevent infections when there are deep and superficial burns or extensive intermediary burns. Centella asiatica extract has proven to be efficient in helping, maintaining and regularizing cicatrisation of skin affected by burns. Its usage combined with an antibiotic agent such as neomycin covers the bacterial spectrum for gram-positive or -negative microorganisms, guaranteeing an anti-infectious efficiency for this extract.
Subject(s)
Anti-Bacterial Agents/administration & dosage , Burns/drug therapy , Centella , Neomycin/administration & dosage , Phytotherapy , Plant Extracts , Administration, Topical , Drug Combinations , HumansABSTRACT
Una quemadura es una lesión que provoca alteraciones en la piel que varían desde el eritema local hasta la destrucción total de la misma. Independien-temente de su magnitud es suficiente la lesión del estrato córneo para que la piel pierda su capacidad como barrera protectora. Por esta razón, un aspecto muy importante del tratamiento de las quemaduras pasa por conseguir la rápida reepitelización de los tejidos destruidos y evitar la infección. La Blastoestimulina® es un producto farmacéutico que asocia una sustancia reepitelizante, la Centella asiática, con un agente antibiótico, la neomicina. El extracto de Centella asiática se ha demostrado eficaz en la inducción, mantenimiento y regularización de la lesión, en tanto que la neomicina es un antibiótico que cubre perfectamente el espectro bacteriano frente a microorganismos grampositivos y negativos. Ofrece excelentes resultados en el tratamiento de las quemaduras ya que favorece la cicatrización de la herida, reduce la inflamación y previene su contaminación
A burn is a tissue lesion which provokes different alterations that vary from topical erythema to total destruction of the structures affected. A burn always produces an alteration in the skin, a lesion in the corneal strata is sufficient to cause the skin to lose its capacity to act as a barrier. The objective the treatment for a burn has i to produce epithelization as soon as possible in order to prevent infection and to reduce functional and esthetic aftereffects. Infection is the main cause of death due to burns due to the growth of endogenous flora or due to external contamination. The use of topical chemotherapy is fundamental to prevent infections when there are deep and superficial burns or extensive intermediary burns. Centella asiatica extract has proven to be efficient in helping, maintaining and regularizing cicatrisation of skin affected by burns. Its usage combined with an antibiotic agent such as neomycin covers the bacterial spectrum for grampositive or -negative microorganisms, guaranteeing an anti-infectious efficiency for this extract
Subject(s)
Humans , Anti-Bacterial Agents/administration & dosage , Burns/drug therapy , Centella , Neomycin/administration & dosage , Phytotherapy , Plant Extracts , Administration, Topical , Drug CombinationsABSTRACT
Asian yellow-flower crowfoot is a plant which has been used for therapeutic purposes for more than 3000 years. Its main active ingredients are asiaticóside and madecasóside which give it a cicatrizing action as well as being a tonic for the blood. At present time, Asian yellow-flower crowfoot extract is indicated to treat ulcers, sores, scabs, and some types of burns. It is also used as a secondary helping agent to treat surgical wounds and to help skin grafts take root. Its use in the form of vaginal ovules make it be an appropriate treatment for some vaginal diseases. This extract is currently found in diverse medical preparations under the trade name "Blastoestimulina". Numerous studies are underway in the scientific field with the objective of discovering new therapeutic uses for this plant.